Detailed view for LOAG_04261

Basic information

TDR Targets ID: 946302
Loa Loa (eye worm), TPR Domain containing protein
Source Database / ID:  KEGG  

pI: 5.2546 | Length (AA): 1155 | MW (Da): 134967 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13374   Tetratricopeptide repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
52 408 4i9c (A) 4 364 13.00 0 1 0.385991 0.29
119 209 2wqh (A) 26 104 34.00 0.19 0.3 0.304488 -0.19
134 240 3ro3 (A) 227 344 27.00 0.0081 0.75 0.367341 -0.43
459 559 3ro3 (A) 236 340 15.00 0.003 0.19 0.287246 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126634)

Species Accession Gene Product
Arabidopsis thaliana AT3G27960   tetratricopeptide repeat domain-containing protein
Arabidopsis thaliana AT1G27500   tetratricopeptide repeat domain-containing protein
Arabidopsis thaliana AT4G10840   protein KINESIN LIGHT CHAIN-RELATED 1
Babesia bovis BBOV_IV009180   hypothetical protein
Brugia malayi Bm1_11290   TPR Domain containing protein
Dictyostelium discoideum DDB_G0292714   hypothetical protein
Giardia lamblia GL50803_11177   Kinesin-like protein
Leishmania braziliensis LbrM.34.0680   hypothetical protein, conserved
Leishmania donovani LdBPK_350700.1   Tetratricopeptide repeat, putative
Leishmania infantum LinJ.35.0700   hypothetical protein, conserved
Leishmania major LmjF.35.0690   hypothetical protein, conserved
Leishmania mexicana LmxM.34.0690   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04261   TPR Domain containing protein
Mus musculus 102634091   predicted gene, 31757
Oryza sativa 4330477   Os02g0708400
Oryza sativa 4328037   Os02g0109800
Onchocerca volvulus OVOC8007   Tetratricopeptide repeat protein 28 homolog
Plasmodium berghei PBANKA_1355400   tetratricopeptide repeat protein, putative
Plasmodium falciparum PF3D7_1342300   tetratricopeptide repeat protein, putative
Plasmodium knowlesi PKNH_1259100   tetratricopeptide repeat protein, putative
Plasmodium vivax PVX_083015   hsp70 interacting protein, putative
Plasmodium yoelii PY01575   hypothetical protein
Schmidtea mediterranea mk4.002060.00  
Trypanosoma brucei gambiense Tbg972.10.4690   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.3770   predicted TPR repeat protein
Trypanosoma congolense TcIL3000_10_3100   predicted TPR repeat protein
Trypanosoma cruzi TcCLB.511001.180   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509017.40   hypothetical protein, conserved
Theileria parva TP01_0854   hypothetical protein

Essentiality

LOAG_04261 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.3770 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.3770 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.3770 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.3770 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_04261 (Loa Loa (eye worm)), TPR Domain containing protein
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