pI: 4.1677 |
Length (AA): 91 |
MW (Da): 9938 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 86 | 3pgg (A) | 25 | 113 | 61.00 | 0 | 1 | 1.63945 | -1.22 |
13 | 86 | 4emk (A) | 6 | 77 | 67.00 | 0 | 1 | 1.68419 | -1.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129070)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G48870 | U6 snRNA-associated Sm-like protein LSM5 |
Babesia bovis | BBOV_IV009630 | snRNP Sm-like protein, putative |
Brugia malayi | Bm1_50275 | U6 snRNA-associated Sm-like protein LSm5 |
Candida albicans | CaO19.7256 | Sm-like protein similar to S. pombe Lsm5 (SPBC20F10.09) and to S. cerevisiae LSM5 (YER146W) subunit of Lsm1-7p and Lsm2-8p compl |
Caenorhabditis elegans | CELE_F28F8.3 | Protein LSM-5 |
Cryptosporidium hominis | Chro.70505 | U6 snRNA associated SM-like protein LSM5 |
Cryptosporidium parvum | cgd7_4580 | U6 snRNA-associated Sm-like protein LSm5. SM domain |
Dictyostelium discoideum | DDB_G0268716 | LSM domain-containing protein |
Drosophila melanogaster | Dmel_CG6610 | CG6610 gene product from transcript CG6610-RA |
Echinococcus granulosus | EgrG_000482100 | U6 snRNA associated Sm protein LSm5 |
Entamoeba histolytica | EHI_076840 | LSM domain containing protein |
Echinococcus multilocularis | EmuJ_000482100 | U6 snRNA associated Sm protein LSm5 |
Homo sapiens | ENSG00000106355 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
Loa Loa (eye worm) | LOAG_03146 | hypothetical protein |
Mus musculus | ENSMUSG00000091625 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
Mus musculus | 102641341 | U6 snRNA-associated Sm-like protein LSm5-like |
Neospora caninum | NCLIV_065170 | snRNP protein Lsm5, putative |
Oryza sativa | 4338670 | Os05g0389300 |
Plasmodium berghei | PBANKA_1307200 | U6 snRNA-associated Sm-like protein LSm5, putative |
Plasmodium falciparum | PF3D7_1443300 | U6 snRNA-associated Sm-like protein LSm5, putative |
Plasmodium knowlesi | PKNH_1239000 | U6 snRNA-associated Sm-like protein LSm5, putative |
Plasmodium vivax | PVX_118325 | U6 snRNA-associated Sm-like protein LSm5, putative |
Saccharomyces cerevisiae | YER146W | RNA-binding protein LSM5 |
Schistosoma japonicum | Sjp_0012260 | U6 snRNA-associated Sm-like protein LSm5, putative |
Schistosoma mansoni | Smp_129760 | hypothetical protein |
Schmidtea mediterranea | mk4.000843.09 | U6 snRNA-associated Sm-like protein LSm5 |
Toxoplasma gondii | TGME49_247610 | small nuclear ribonucleoprotein E, putative |
Theileria parva | TP01_0806 | U6 small nuclear ribonucleoprotein E, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F28F8.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F28F8.3 | Caenorhabditis elegans | sterile | wormbase |
YER146W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1307200 | Plasmodium berghei | Essential | plasmo |
TGME49_247610 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.