Detailed view for LOAG_02506

Basic information

TDR Targets ID: 947012
Loa Loa (eye worm), MBD3 protein
Source Database / ID:  KEGG  

pI: 10.5513 | Length (AA): 216 | MW (Da): 23734 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14048   C-terminal domain of methyl-CpG binding protein 2 and 3
PF16564   p55-binding region of Methyl-CpG-binding domain proteins MBD

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
165 210 5ifs (A) 326 369 20.00 0.054 0.05 0.413663 -0.61

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131933)

Species Accession Gene Product
Brugia malayi Bm1_26070   MBD3 protein
Drosophila melanogaster Dmel_CG8208   CG8208 gene product from transcript CG8208-RC
Echinococcus granulosus EgrG_001033700   methyl CpG binding domain protein 2
Echinococcus multilocularis EmuJ_001033700   methyl CpG binding domain protein 2
Homo sapiens ENSG00000071655   methyl-CpG binding domain protein 3
Homo sapiens ENSG00000134046   methyl-CpG binding domain protein 2
Loa Loa (eye worm) LOAG_02506   MBD3 protein
Mus musculus ENSMUSG00000035478   methyl-CpG binding domain protein 3
Mus musculus ENSMUSG00000024513   methyl-CpG binding domain protein 2
Schistosoma japonicum Sjp_0103250   Methyl-CpG-binding domain protein 2, putative
Schistosoma mansoni Smp_138180.2   methyl-cpg binding protein mbd
Schistosoma mansoni Smp_138180.1   methyl-cpg binding protein mbd
Schmidtea mediterranea mk4.000465.10   Methyl-CpG binding domain 2/3

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens methyl-CpG binding domain protein 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0336 0.4039 1
0.0179 0.8261 1
0.0289 0.2803 1
0.0294 0.3609 0.5862
0.0308 0.3792 0.6162
0.0336 0.4039 1
0.013 0.2638 0.5384

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_02506 (Loa Loa (eye worm)), MBD3 protein
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