Detailed view for LOAG_02782

Basic information

TDR Targets ID: 947489
Loa Loa (eye worm), leucine Rich Repeat family protein
Source Database / ID:  KEGG  

pI: 9.0069 | Length (AA): 1264 | MW (Da): 144984 | Paralog Number: 0

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13306   Leucine rich repeats (6 copies)
PF13855   Leucine rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
48 160 4p8s (A) 29 147 27.00 0.000005 0.98 0.343399 -0.73
49 763 5gmh (A) 27 786 30.00 0 1 0.713465 0.58
50 229 4rca (B) 25 189 31.00 0.0000021 1 0.386205 0.02
53 160 4li1 (B) 146 244 26.00 0.0017 0.99 0.393443 -0.86
55 134 2ell (A) 33 110 14.00 0.77 0.09 0.0872911 0.48
75 801 4mn8 (A) 52 775 25.00 0 1 0.767958 0.73
80 278 6dbg (A) 39 223 32.00 0.00000067 1 0.540237 -0.67
120 277 4r58 (A) 64 209 43.00 0.000000000076 1 0.6708 -1.2
292 1000 3wpe (A) 67 760 29.00 0 1 0.649718 0.77
774 905 2v70 (A) 533 665 30.00 0.000000071 1 0.57623 -1.06
1058 1209 2ifg (A) 57 175 33.00 0.14 0.19 0.115053 0.7
1097 1234 6bxd (A) 81 211 21.00 0.000000059 0.49 0.281177 -0.2
1117 1232 3b2d (A) 521 626 19.00 0.000036 0.14 0.203772 -0.45
1119 1208 2v70 (A) 612 694 30.00 0.0000093 0.9 0.338203 -0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_144049)

Species Accession Gene Product
Brugia malayi Bm1_35345   Leucine Rich Repeat family protein
Caenorhabditis elegans CELE_C56E6.6   Protein LRON-15
Drosophila melanogaster Dmel_CG4168   CG4168 gene product from transcript CG4168-RC
Loa Loa (eye worm) LOAG_02782   leucine Rich Repeat family protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_02782 (Loa Loa (eye worm)), leucine Rich Repeat family protein
Title for this comment
Comment