Detailed view for LOAG_15229

Basic information

TDR Targets ID: 947736
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.9469 | Length (AA): 91 | MW (Da): 10488 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00147   Fibrinogen beta and gamma chains, C-terminal globular domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 50 1m1j (B) 247 306 50.00 0.00000027 0.87 0.826051 0.64
1 91 2d39 (B) 148 231 38.00 0.0000016 1 1.3565 0.35
1 71 2j1g (B) 110 172 51.00 0.00000000017 0.79 1.17182 0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127084)

Species Accession Gene Product
Caenorhabditis elegans CELE_D1009.3   Protein D1009.3, isoform A
Drosophila melanogaster Dmel_CG30280   CG30280 gene product from transcript CG30280-RB
Giardia lamblia GL50803_16477   Tenascin-37
Homo sapiens ENSG00000168477   tenascin XB
Homo sapiens ENSG00000085265   ficolin (collagen/fibrinogen domain containing) 1
Homo sapiens ENSG00000160339   ficolin (collagen/fibrinogen domain containing lectin) 2
Homo sapiens ENSG00000041982   tenascin C
Homo sapiens ENSG00000116147   tenascin R
Homo sapiens ENSG00000120332   tenascin N
Homo sapiens ENSG00000130720   fibrinogen C domain containing 1
Loa Loa (eye worm) LOAG_15229   hypothetical protein
Mus musculus ENSMUSG00000026938   ficolin A
Mus musculus ENSMUSG00000033327   tenascin XB
Mus musculus ENSMUSG00000026835   ficolin B
Mus musculus ENSMUSG00000026841   fibrinogen C domain containing 1
Mus musculus ENSMUSG00000015829   tenascin R
Mus musculus ENSMUSG00000028364   tenascin C
Mus musculus ENSMUSG00000026725   tenascin N
Onchocerca volvulus OVOC1967  
Schmidtea mediterranea mk4.001395.02  
Schmidtea mediterranea mk4.000663.03  
Schmidtea mediterranea mk4.001395.00  
Toxoplasma gondii TGME49_312540   hypothetical protein

Essentiality

LOAG_15229 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_312540 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_15229 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment