Detailed view for LOAG_10800

Basic information

TDR Targets ID: 947985
Loa Loa (eye worm), FAT-3 protein
Source Database / ID:  KEGG  

pI: 7.7328 | Length (AA): 452 | MW (Da): 52752 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00487   Fatty acid desaturase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016491   oxidoreductase activity  
GO:0006629   lipid metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 32 1kbi (A) 18 48 13.00 0.25 0.07 0.241384 -0.64
8 65 1x3x (A) 19 75 32.00 0 1 0.599419 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128446)

Species Accession Gene Product
Arabidopsis thaliana AT2G46210   Fatty acid/sphingolipid desaturase
Arabidopsis thaliana AT3G61580   Fatty acid/sphingolipid desaturase
Brugia malayi Bm1_02155   Delta5 fatty acid desaturase
Candida albicans CaO19.7892   similar to Mucor rouxii delta(6)-desaturase which converts linoleic acid to Gamma-linolenic acid
Candida albicans CaO19.260   similar to Mucor rouxii delta(6)-desaturase which converts linoleic acid to Gamma-linolenic acid
Caenorhabditis elegans CELE_W08D2.4   Protein FAT-3, isoform C
Caenorhabditis elegans CELE_T13F2.1   Protein FAT-4, isoform C
Homo sapiens ENSG00000134824   fatty acid desaturase 2
Homo sapiens ENSG00000221968   fatty acid desaturase 3
Homo sapiens ENSG00000149485   fatty acid desaturase 1
Leishmania braziliensis LbrM.07.1160   delta-5 fatty acid desaturase, putative
Leishmania donovani LdBPK_071260.1   fatty acid desaturase, putative
Leishmania infantum LinJ.07.1260   delta-5 fatty acid desaturase, putative
Leishmania major LmjF.07.1090   delta-5 fatty acid desaturase
Leishmania mexicana LmxM.07.1090   fatty acid desaturase, putative
Loa Loa (eye worm) LOAG_10800   FAT-3 protein
Loa Loa (eye worm) LOAG_15543   hypothetical protein
Loa Loa (eye worm) LOAG_15426   hypothetical protein
Mus musculus 228151   RIKEN cDNA 4833423E24 gene
Mus musculus ENSMUSG00000010663   fatty acid desaturase 1
Mus musculus ENSMUSG00000024664   fatty acid desaturase 3
Mus musculus ENSMUSG00000024665   fatty acid desaturase 2
Oryza sativa 4346776   Os09g0338500
Onchocerca volvulus OVOC13495  
Schistosoma japonicum Sjp_0302110   ko:K10226 fatty acid desaturase 2, putative
Schistosoma mansoni Smp_132740   fatty acid desaturase
Schmidtea mediterranea mk4.016579.00   Fads2 protein
Schmidtea mediterranea mk4.010120.02   Fatty acid desaturase, putative

Essentiality

LOAG_10800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W08D2.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens fatty acid desaturase 1 Compounds References
Rattus norvegicus Fatty acid desaturase 1 Compounds References
Homo sapiens fatty acid desaturase 2 Compounds References
Rattus norvegicus Fatty acid desaturase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0096 0.5176 0.5105
0.0073227 0.998805 1
0.0431 0.4076 0.3977
0.0150042 0.998701 1
0.0258 0.9965 1
0.0209 0.2818 1
0.0312 0.3599 1
0.0225 0.2796 0.2784
0.0611 0.3184 0.3171
0.024 0.3009 0.3416
0.0462 0.4418 0.4775
0.0607 0.9967 1
0.0401 0.4443 0.4422
0.024 0.9927 1
0.062 0.2886 0.2981
0.0333 0.3213 0.38
0.051 0.5919 1
0.0205 0.4672 0.6987
0.103 0.4532 0.4781
0.0234 0.3398 0.3728
0.0408 0.9753 1
0.0315 0.5503 0.7166
0.0243 0.379 0.6139
0.024 0.2938 1
0.0611 0.3184 0.3171
0.0258 0.986 1
0.0225 0.2796 0.2784
0.0073227 0.998805 1
0.0625 0.3137 0.325
0.0242 0.3049 1
0.0462 0.4418 0.4775
0.0198 0.2865 1
0.024 0.9927 1
0.0109 0.3527 1
0.0625 0.3137 0.325
0.0296 0.2798 0.399
0.01 0.2707 0.6791
0.0107 0.6228 1
0.0303 0.6061 1
0.0096 0.3149 0.3149
0.0113 0.7677 0.7677
0.0258 0.5078 0.5276
0.0221 0.2953 0.4247
0.0102 0.588 0.5105
0.0312 0.3599 1
0.0101 0.9965 1
0.0102 0.588 0.5105

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_10800 (Loa Loa (eye worm)), FAT-3 protein
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