Detailed view for LOAG_00891

Basic information

TDR Targets ID: 948168
Loa Loa (eye worm), NADH-ubiquinone oxidoreductase 19 kDa subunit
Source Database / ID:  KEGG  

pI: 7.4575 | Length (AA): 182 | MW (Da): 21461 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
47 130 2ykt (A) 120 214 30.00 0.58 0.03 0.592138 0.05
80 116 2k3j (A) 68 104 19.00 0.67 0.3 0.490697 -0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129973)

Species Accession Gene Product
Arabidopsis thaliana AT5G18800   NADH dehydrogenase [ubiquinone] 1 alpha subcomplex 8-B
Brugia malayi Bm1_45585   NADH-ubiquinone oxidoreductase 19 kDa subunit
Candida albicans CaO19.2821   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to N. crassa CI-20.8kd subunit, mammalian CI-19
Candida albicans CaO19.10339   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to N. crassa CI-20.8kd subunit, mammalian CI-19
Caenorhabditis elegans CELE_Y54F10AM.5   Protein Y54F10AM.5
Dictyostelium discoideum DDB_G0284799   CHCH domain-containing protein
Drosophila melanogaster Dmel_CG3683   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8
Echinococcus granulosus EgrG_000755550   NADH dehydrogenase (ubiquinone) 1 alpha
Echinococcus multilocularis EmuJ_000755550   hypothetical protein
Homo sapiens ENSG00000119421   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
Loa Loa (eye worm) LOAG_00891   NADH-ubiquinone oxidoreductase 19 kDa subunit
Mus musculus ENSMUSG00000026895   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8
Oryza sativa 4332532   Os03g0295500
Onchocerca volvulus OVOC8365   NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 homolog
Schistosoma japonicum Sjp_0055480   ko:K03952 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 8, putative
Schistosoma mansoni Smp_027480   hypothetical protein
Schmidtea mediterranea mk4.004428.00   NADH dehydrogenase

Essentiality

LOAG_00891 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y54F10AM.5 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_00891 (Loa Loa (eye worm)), NADH-ubiquinone oxidoreductase 19 kDa subunit
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