Detailed view for LOAG_01667

Basic information

TDR Targets ID: 948979
Loa Loa (eye worm), CK1/WORM6 protein kinase
Source Database / ID:  KEGG  

pI: 7.9806 | Length (AA): 344 | MW (Da): 39916 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
24 333 5czo (A) 5 297 23.00 0 1 1.02506 0.54
26 56 6di1 (A) 401 431 35.00 0 0.81 0.460016 0.04
27 328 4nfn (A) 34 312 43.00 0 1 1.29941 -0.19
138 181 3hko (A) 162 207 48.00 0.005 0.75 0.536407 0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127858)

Species Accession Gene Product
Brugia malayi Bm1_34595   Protein kinase domain containing protein
Brugia malayi Bm1_02215   Protein kinase domain containing protein
Brugia malayi Bm1_29635   Protein kinase domain containing protein
Brugia malayi Bm1_43435   Protein kinase domain containing protein
Brugia malayi Bm1_52350   Protein kinase domain containing protein
Caenorhabditis elegans CELE_B0218.5   Protein B0218.5
Caenorhabditis elegans CELE_C08F8.6   Protein C08F8.6
Caenorhabditis elegans CELE_R90.1   Protein R90.1
Caenorhabditis elegans CELE_F41G3.5   Protein F41G3.5
Dictyostelium discoideum DDB_G0292354   TTBK family protein kinase
Drosophila melanogaster Dmel_CG11533   CG11533 gene product from transcript CG11533-RI
Echinococcus granulosus EgrG_000922600   tau tubulin kinase 1
Echinococcus granulosus EgrG_001126800   serine threonine protein kinase
Echinococcus granulosus EgrG_000581400   tau tubulin kinase 1
Echinococcus multilocularis EmuJ_000581400   tau tubulin kinase 1
Echinococcus multilocularis EmuJ_000922600   tau tubulin kinase 1
Echinococcus multilocularis EmuJ_001126800   serine threonine protein kinase
Homo sapiens 146057   tau tubulin kinase 2
Homo sapiens ENSG00000146216   tau tubulin kinase 1
Leishmania braziliensis LbrM.20.2600   protein kinase, putative
Leishmania donovani LdBPK_342850.1   protein kinase, putative
Leishmania infantum LinJ.34.2850   protein kinase, putative
Leishmania major LmjF.34.3020   protein kinase, putative
Leishmania mexicana LmxM.33.3020   protein kinase, putative
Loa Loa (eye worm) LOAG_01187   CK1/WORM6 protein kinase
Loa Loa (eye worm) LOAG_06709   CK1 protein kinase
Loa Loa (eye worm) LOAG_10078   hypothetical protein
Loa Loa (eye worm) LOAG_12936   CK1/TTBK protein kinase
Loa Loa (eye worm) LOAG_01194   CK1/WORM6 protein kinase
Loa Loa (eye worm) LOAG_06586   CK1/TTBKL protein kinase
Loa Loa (eye worm) LOAG_04691   CK1/TTBK protein kinase
Loa Loa (eye worm) LOAG_01667   CK1/WORM6 protein kinase
Mus musculus ENSMUSG00000015599   tau tubulin kinase 1
Mus musculus ENSMUSG00000090100   tau tubulin kinase 2
Onchocerca volvulus OVOC7379  
Onchocerca volvulus OVOC6251   Asator homolog
Onchocerca volvulus OVOC2497  
Onchocerca volvulus OVOC6183  
Onchocerca volvulus OVOC10546  
Onchocerca volvulus OVOC6596  
Onchocerca volvulus OVOC2593  
Schistosoma japonicum Sjp_0001590   ko:K08815 tau tubulin kinase, putative
Schistosoma japonicum Sjp_0004870   Tau-tubulin kinase 1, putative
Schistosoma mansoni Smp_133420   serine/threonine protein kinase
Schistosoma mansoni Smp_097820   serine/threonine protein kinase
Schmidtea mediterranea mk4.001942.06   Serine/threonine kinase
Schmidtea mediterranea mk4.000006.19   Serine/threonine kinase
Schmidtea mediterranea mk4.004938.01   Serine/threonine kinase
Schmidtea mediterranea mk4.003176.00   Serine/threonine kinase
Schmidtea mediterranea mk4.001942.05   Serine/threonine kinase
Schmidtea mediterranea mk4.008392.01   Serine/threonine kinase
Schmidtea mediterranea mk4.000220.07   Serine/threonine kinase
Schmidtea mediterranea mk4.001529.06   Protein kinase
Trypanosoma brucei gambiense Tbg972.4.1610   protein kinase, putative
Trypanosoma brucei Tb927.4.1700   CK1/TTBK protein kinase, putative
Trypanosoma congolense TcIL3000_4_1320   protein kinase, putative
Trypanosoma cruzi TcCLB.504057.170   CK1/TTBK protein kinase, putative
Trichomonas vaginalis TVAG_274610   CK1 family protein kinase
Trichomonas vaginalis TVAG_100730   CK1 family protein kinase
Trichomonas vaginalis TVAG_185570   CK1 family protein kinase
Trichomonas vaginalis TVAG_099940   CK1 family protein kinase
Trichomonas vaginalis TVAG_489820   CK1 family protein kinase
Trichomonas vaginalis TVAG_133090   CK1 family protein kinase
Trichomonas vaginalis TVAG_425530   CK1 family protein kinase
Trichomonas vaginalis TVAG_127830   CK1 family protein kinase
Trichomonas vaginalis TVAG_425910   CK1 family protein kinase
Trichomonas vaginalis TVAG_284090   CK1 family protein kinase
Trichomonas vaginalis TVAG_440680   CK1 family protein kinase
Trichomonas vaginalis TVAG_394320   CK1 family protein kinase
Trichomonas vaginalis TVAG_050280   CK1 family protein kinase
Trichomonas vaginalis TVAG_457910   CK1 family protein kinase
Trichomonas vaginalis TVAG_364400   CK1 family protein kinase
Trichomonas vaginalis TVAG_245000   CK1 family protein kinase
Trichomonas vaginalis TVAG_127390   CK1 family protein kinase
Trichomonas vaginalis TVAG_088090   CK1 family protein kinase
Trichomonas vaginalis TVAG_528260   CK1 family protein kinase
Trichomonas vaginalis TVAG_165220   CK1 family protein kinase
Trichomonas vaginalis TVAG_388610   CK1 family protein kinase
Trichomonas vaginalis TVAG_165540   CK1 family protein kinase
Trichomonas vaginalis TVAG_376520   CK1 family protein kinase
Trichomonas vaginalis TVAG_367390   CK1 family protein kinase
Trichomonas vaginalis TVAG_159850   CK1 family protein kinase
Trichomonas vaginalis TVAG_345910   CK1 family protein kinase
Trichomonas vaginalis TVAG_068970   CK1 family protein kinase
Trichomonas vaginalis TVAG_307020   CK1 family protein kinase
Trichomonas vaginalis TVAG_149990   casein kinase, putative
Trichomonas vaginalis TVAG_315860   CK1 family protein kinase
Trichomonas vaginalis TVAG_433040   CK1 family protein kinase
Trichomonas vaginalis TVAG_460900   CK1 family protein kinase

Essentiality

LOAG_01667 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.1700 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.1700 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.1700 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.1700 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R90.1 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Casein kinase I isoform alpha 325 aa 29.4% 310 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0007 0.5 0.5
0.0059 1 1
0.0008 0.5 0.5
0.0067 0.5 0.5
0.0036 0.5 0.5
0.0062 0.6935 0.6935
0.0061 0.6883 0.6883
0.0007 0.5 0.5
0.0033 0.5 0.5
0.0081 0.5 0.5
0.0012 0.5 0.5
0.0011 1 1
0.0003 0.5 0.5
0.0018 0.5 0.5
0.0092 1 1
0.0004 0.5 0.5
0.0066 0.3101 0.3068
0.0026 0.5 0.5
0.0069 0.3067 0.9179
0.0029 0.5 0.5
0.0007 0.5 0.5
0.0042 0.5 0.5
0.0088 0.4477 0.4477
0.0023 0.5 0.5
0.0037 1 0.5
0.0016 0.5 0.5
0.0063 0.7244 0.6686
0.0056 1 1
0.0059 1 1
0.0033 1 1
0.0022 0.5 0.5
0.0064 0.3377 0.3377
0.0081 1 1
0.0091 1 1
0.0032 0.5 0.5
0.0012 0.5 0.5
0.0027 1 1
0.0039 0.5 0.5
0.0093 0.8828 0.8828
0.0063 1 1
0.0016 0.5 0.5
0.0032 0.5 0.5
0.0098 0.3242 0.3017
0.0012 0.5 0.5
0.0039 0.5 0.5
0.0039 0.9485 1
0.0059 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LOAG_01667 (Loa Loa (eye worm)), CK1/WORM6 protein kinase
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