Detailed view for LOAG_01860

Basic information

TDR Targets ID: 948996
Loa Loa (eye worm), AIDA-1b
Source Database / ID:  KEGG  

pI: 6.7063 | Length (AA): 1313 | MW (Da): 144230 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00536   SAM domain (Sterile alpha motif)
PF00640   Phosphotyrosine interaction domain (PTB/PID)
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 304 5g4x (A) 55 339 26.00 0.0000096 1 0.377891 0.73
62 184 4gmr (A) 35 155 46.00 0 1 0.664179 -0.72
62 151 2zgd (A) 22 109 31.00 0 1 0.551045 -1.35
101 305 1n11 (A) 407 593 36.00 0 1 0.463631 0.01
217 267 4bsz (B) 54 115 45.00 0.29 1 0.320342 0.47
224 290 1ycs (B) 338 405 34.00 0.084 1 0.514528 -0.45
246 421 4o60 (A) 6 201 18.00 0.0000055 1 0.210044 0.04
1056 1123 5zrz (A) 804 869 35.00 0.00000000078 1 0.62179 -1.9
1160 1313 1wj1 (A) 2 154 27.00 0 1 0.428289 -0.21
1164 1302 3f0w (A) 59 195 32.00 0.00000016 1 0.488364 -0.44
1176 1304 2m38 (A) 12 146 43.00 0 1 0.629248 -0.81
1185 1309 3so6 (A) 47 174 27.00 0 0.98 0.492202 -0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132174)

Species Accession Gene Product
Brugia malayi Bm1_40280   AIDA-1b
Caenorhabditis elegans CELE_C11E4.6   Protein C11E4.6
Drosophila melanogaster Dmel_CG11168   CG11168 gene product from transcript CG11168-RC
Drosophila melanogaster Dmel_CG4393   CG4393 gene product from transcript CG4393-RD
Homo sapiens ENSG00000185046   ankyrin repeat and sterile alpha motif domain containing 1B
Homo sapiens ENSG00000064999   ankyrin repeat and sterile alpha motif domain containing 1A
Loa Loa (eye worm) LOAG_01860   AIDA-1b
Mus musculus ENSMUSG00000058589   ankyrin repeat and sterile alpha motif domain containing 1B
Mus musculus ENSMUSG00000024219   ankyrin repeat and SAM domain containing 1
Onchocerca volvulus OVOC5201  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_01860 (Loa Loa (eye worm)), AIDA-1b
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