Detailed view for LOAG_07484

Basic information

TDR Targets ID: 949144
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.1112 | Length (AA): 1051 | MW (Da): 119571 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07842   GC-rich sequence DNA-binding factor-like protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005634   nucleus  
GO:0003700   transcription factor activity  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 185 5vjt (A) 4 195 8.00 0.024 0 0.25372 -0.86
213 523 5hm5 (A) 321 714 28.00 0.64 0.99 0.314409 1.05
262 465 2yfa (A) 73 278 11.00 0 0.02 0.321801 -0.98
407 467 3cve (A) 288 352 39.00 0.48 0.1 0.37554 -0.23
956 1005 2nps (B) 184 233 30.00 0.25 0.03 0.349174 -0.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131106)

Species Accession Gene Product
Arabidopsis thaliana AT5G08550   GC-rich sequence DNA-binding factor-like protein ILP1
Brugia malayi Bm1_12115   SNARE domain containing protein
Caenorhabditis elegans CELE_F43G9.12   Protein F43G9.12, isoform B
Dictyostelium discoideum DDB_G0288089   GC-rich sequence DNA-binding factor-like protein
Drosophila melanogaster Dmel_CG1965   CG1965 gene product from transcript CG1965-RC
Echinococcus granulosus EgrG_000627200   GC rich sequence DNA binding factor 1
Echinococcus multilocularis EmuJ_000627200   GC rich sequence DNA binding factor 1
Homo sapiens ENSG00000159086   PAX3 and PAX7 binding protein 1
Loa Loa (eye worm) LOAG_07484   hypothetical protein
Mus musculus ENSMUSG00000022974   PAX3 and PAX7 binding protein 1
Oryza sativa 4334819   Os03g0853700
Onchocerca volvulus OVOC13414  
Onchocerca volvulus OVOC442  
Schistosoma japonicum Sjp_0300170   ko:K09061 GC-rich sequence DNA-binding factor, putative
Schistosoma mansoni Smp_170250   gc-rich sequence DNA-binding factor
Schmidtea mediterranea mk4.000266.05   Putative gc-rich sequence DNA-binding factor

Essentiality

LOAG_07484 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F43G9.12 Caenorhabditis elegans embryonic lethal wormbase
CELE_F43G9.12 Caenorhabditis elegans larval arrest wormbase
CELE_F43G9.12 Caenorhabditis elegans slow growth wormbase
CELE_F43G9.12 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_07484 (Loa Loa (eye worm)), hypothetical protein
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