Detailed view for LOAG_07589

Basic information

TDR Targets ID: 950631
Loa Loa (eye worm), cation efflux family protein
Source Database / ID:  KEGG  

pI: 9.1823 | Length (AA): 426 | MW (Da): 47155 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01545   Cation efflux family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0008324   cation transmembrane transporter activity  
GO:0055085   transmembrane transport  
GO:0006812   cation transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 106 5a3d (A) 193 295 14.00 0.55 0.08 0.228315 -0.13
352 425 2zzt (A) 209 283 16.00 0.097 0.27 0.341409 -0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131446)

Species Accession Gene Product
Arabidopsis thaliana AT1G51610   metal tolerance protein C4
Brugia malayi Bm1_19360   cation efflux family protein
Caenorhabditis elegans CELE_Y71H2AM.9   Protein Y71H2AM.9
Drosophila melanogaster Dmel_CG8632   Zinc transporter 49B
Echinococcus granulosus EgrG_000449000   zinc transporter 9
Echinococcus granulosus EgrG_000480100   leucine rich repeat containing protein 23
Echinococcus multilocularis EmuJ_000449000   zinc transporter 9
Echinococcus multilocularis EmuJ_000480100   leucine rich repeat containing protein 23
Homo sapiens 10463   solute carrier family 30 (zinc transporter), member 9
Loa Loa (eye worm) LOAG_07589   cation efflux family protein
Mus musculus 109108   solute carrier family 30 (zinc transporter), member 9
Oryza sativa 9269174   Os04g0298366
Onchocerca volvulus OVOC7743   Zinc transporter 9 homolog
Schistosoma japonicum Sjp_0219630   IPR009061,Putative DNA binding,domain-containing
Schistosoma japonicum Sjp_0131740   hypothetical protein
Schistosoma japonicum Sjp_0135150   Zinc transporter 9, putative
Schistosoma japonicum Sjp_0215680   Leucine-rich repeat-containing protein 23, putative
Schistosoma mansoni Smp_162450   expressed protein
Schmidtea mediterranea mk4.000070.07   Zinc transporter 9

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_07589 (Loa Loa (eye worm)), cation efflux family protein
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