Detailed view for LOAG_03903

Basic information

TDR Targets ID: 950811
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 7.1088 | Length (AA): 910 | MW (Da): 103478 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01663   Type I phosphodiesterase / nucleotide pyrophosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0051377   mannose-ethanolamine phosphotransferase activity  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  
GO:0006506   GPI anchor biosynthetic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
77 286 5veo (A) 28 243 22.00 0.99 0.98 0.370169 -0.09
216 293 5tcd (A) 176 258 27.00 0.0036 0.65 0.366114 -0.13
238 286 5egh (A) 192 245 35.00 0.36 0.52 0.315246 0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128399)

Species Accession Gene Product
Arabidopsis thaliana AT5G17250   alkaline-phosphatase-like protein
Brugia malayi Bm1_22750   hypothetical protein
Candida albicans CaO19.833   similar to C terminus of GPI13, GPI anchor synthesis
Candida albicans CaO19.832   truncated form of GPI13, GPI anchor synthesis
Candida albicans CaO19.8452   truncated form of GPI13, GPI anchor synthesis
Candida albicans CaO19.8453   similar to C terminus of GPI13, GPI anchor synthesis
Caenorhabditis elegans CELE_C27A12.9   Protein C27A12.9
Cryptosporidium hominis Chro.80266   CG12263 gene product-related
Cryptosporidium parvum cgd8_2260   phosphatidylinositol glycan class O, integral membrane protein with signal peptide sequence and 12 or more transmembrane domains
Dictyostelium discoideum DDB_G0278687   phosphatidylinositol glycan, class O
Drosophila melanogaster Dmel_CG12263   CG12263 gene product from transcript CG12263-RA
Echinococcus granulosus EgrG_001186800   gpi ethanolamine phosphate transferase 3
Entamoeba histolytica EHI_035390   phosphatidylinositol-glycan biosynthesis class O protein, putative
Entamoeba histolytica EHI_107320   phosphatidylinositol-glycan biosynthesis class O protein, putative
Echinococcus multilocularis EmuJ_001186800   gpi ethanolamine phosphate transferase 3
Homo sapiens ENSG00000165282   phosphatidylinositol glycan anchor biosynthesis, class O
Leishmania braziliensis LbrM.24.0340   ethanolamine phosphotransferase, putative
Leishmania donovani LdBPK_240330.1   ethanolamine phosphotransferase, putative
Leishmania infantum LinJ.24.0330   ethanolamine phosphotransferase, putative
Leishmania major LmjF.24.0340   ethanolamine phosphotransferase, putative
Leishmania mexicana LmxM.24.0340   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_03903   hypothetical protein
Mus musculus ENSMUSG00000028454   phosphatidylinositol glycan anchor biosynthesis, class O
Oryza sativa 4348186   Os10g0170300
Onchocerca volvulus OVOC1248   GPI ethanolamine phosphate transferase 3 homolog
Plasmodium berghei PBANKA_1429900   GPI ethanolamine phosphate transferase 3, putative
Plasmodium falciparum PF3D7_1214100   GPI ethanolamine phosphate transferase 3, putative
Plasmodium knowlesi PKNH_1433600   GPI ethanolamine phosphate transferase 3, putative
Plasmodium yoelii PY02021   Drosophila melanogaster CG12263 gene product-related
Plasmodium yoelii PY02022   hypothetical protein
Saccharomyces cerevisiae YLL031C   Gpi13p
Schistosoma japonicum Sjp_0045610   ko:K05288 phosphatidylinositol glycan, class O, putative
Schistosoma mansoni Smp_021980   hypothetical protein
Schmidtea mediterranea mk4.002558.03  
Trypanosoma brucei gambiense Tbg972.11.5730   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.5070   GPI ethanolamine phosphate transferase 3, putative
Theileria parva TP01_0169   hypothetical protein

Essentiality

LOAG_03903 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.2720 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.2720 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.2720 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.2720 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
YLL031C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1429900 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_03903 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment