Detailed view for MUL_1233

Basic information

TDR Targets ID: 951516
Mycobacterium ulcerans, acyl-CoA dehydrogenase
Source Database / ID:  KEGG  

pI: 5.1765 | Length (AA): 647 | MW (Da): 71895 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00441   Acyl-CoA dehydrogenase, C-terminal domain
PF01756   Acyl-CoA oxidase
PF02770   Acyl-CoA dehydrogenase, middle domain
PF02771   Acyl-CoA dehydrogenase, N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0071949   GO:FAD binding  

GO:0016627   oxidoreductase activity, acting on the CH-CH group of donors  
GO:0005777   peroxisome  
GO:0003997   acyl-CoA oxidase activity  
GO:0050660   FAD binding  
GO:0006631   fatty acid metabolic process  
GO:0055114   oxidation reduction  
GO:0006635   fatty acid beta-oxidation  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 644 5y9d (A) 13 643 28.00 0 1 1.32766 -0.5
1 644 2ddh (A) 1 626 30.00 0 1 1.21966 0.18
52 446 2vig (A) 68 410 27.00 0 1 0.78951 -0.01
105 628 5k3h (A) 119 618 32.00 0 1 1.05739 0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130227)

Species Accession Gene Product
Arabidopsis thaliana AT5G65110   acyl-coenzyme A oxidase 2
Brugia malayi Bm1_20620   hypothetical protein
Caenorhabditis elegans CELE_F58F9.7   Protein F58F9.7
Dictyostelium discoideum DDB_G0286669   acyl-CoA oxidase
Drosophila melanogaster Dmel_CG17544   CG17544 gene product from transcript CG17544-RA
Drosophila melanogaster Dmel_CG9527   CG9527 gene product from transcript CG9527-RD
Homo sapiens ENSG00000087008   acyl-CoA oxidase 3, pristanoyl
Homo sapiens ENSG00000153093   acyl-CoA oxidase-like
Loa Loa (eye worm) LOAG_12572   hypothetical protein
Mus musculus ENSMUSG00000027380   acyl-Coenzyme A oxidase-like
Mus musculus ENSMUSG00000029098   acyl-Coenzyme A oxidase 3, pristanoyl
Mycobacterium ulcerans MUL_1233   acyl-CoA dehydrogenase
Oryza sativa 4350881   Os11g0605500
Schmidtea mediterranea mk4.000260.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_1233 (Mycobacterium ulcerans), acyl-CoA dehydrogenase
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