Detailed view for MUL_2209

Basic information

TDR Targets ID: 951582
Mycobacterium ulcerans, oxidoreductase
Source Database / ID:  KEGG  

pI: 8.5003 | Length (AA): 323 | MW (Da): 33882 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08240   Alcohol dehydrogenase GroES-like domain
PF13602   Zinc-binding dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 323 5a3v (A) 6 329 34.00 0 1 1.4265 -0.52
1 323 2dq4 (A) 1 341 30.00 0.00000000025 1 1.0402 0.49
1 322 2eih (A) 1 341 37.00 0 1 1.3141 -0.08
9 92 4dl9 (A) 16 92 43.00 0.000017 0.48 0.417262 1.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127317)

Species Accession Gene Product
Arabidopsis thaliana AT1G23740   alkenal/one oxidoreductase
Arabidopsis thaliana AT4G13010   putative quinone-oxidoreductase-like protein
Arabidopsis thaliana AT3G15090   GroES-like zinc-binding alcohol dehydrogenase family protein
Brugia malayi Bm1_11580   oxidoreductase, zinc-binding dehydrogenase family protein
Candida albicans CaO19.14158   similar to potential zinc-binding oxidoreductase from B.cereus (NP_833231) and to S. cerevisiae AST2 (YER101C)
Candida albicans CaO19.6869   similar to potential zinc-binding oxidoreductase from B.cereus (NP_833231) and to S. cerevisiae AST2 (YER101C)
Candida albicans CaO19.847   similar to S. cerevisiae VIM1 (YMR152W) mitochondrial inner membrane protease
Candida albicans CaO19.8467   similar to S. cerevisiae VIM1 (YMR152W) mitochondrial inner membrane protease
Caenorhabditis elegans CELE_F56H1.6   Protein RAD-8
Dictyostelium discoideum DDB_G0288729   zinc-containing alcohol dehydrogenase
Drosophila melanogaster Dmel_CG17221   CG17221 gene product from transcript CG17221-RB
Echinococcus granulosus EgrG_000090500   reticulon 4 interacting protein 1
Echinococcus multilocularis EmuJ_000090500   reticulon 4 interacting protein 1
Homo sapiens 84816   reticulon 4 interacting protein 1
Loa Loa (eye worm) LOAG_12185   oxidoreductase
Mus musculus ENSMUSG00000019864   reticulon 4 interacting protein 1
Mycobacterium ulcerans MUL_2209   oxidoreductase
Oryza sativa 4347491   Os09g0502500
Oryza sativa 9266087   Os04g0358000
Oryza sativa 4345439   Os08g0379400
Oryza sativa 4327011   Os01g0753100
Oryza sativa 4335575   Os04g0359700
Oryza sativa 4335574   Os04g0359100
Saccharomyces cerevisiae YMR152W   Yim1p
Schistosoma japonicum Sjp_0031190   ko:K03750 molybdopterin biosynthesis protein MoeA, putative
Schistosoma mansoni Smp_067400   zinc binding dehydrogenase
Schmidtea mediterranea mk4.011034.00  
Schmidtea mediterranea mk4.011612.00  
Schmidtea mediterranea mk4.002001.02   Zinc binding dehydrogenase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_2209 (Mycobacterium ulcerans), oxidoreductase
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