Detailed view for MUL_2219

Basic information

TDR Targets ID: 952039
Mycobacterium ulcerans, transposase for IS2606
Source Database / ID:  KEGG  

pI: 6.9654 | Length (AA): 444 | MW (Da): 49031 | Paralog Number: 78

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00872   Transposase, Mutator family

Gene Ontology

Mouse over links to read term descriptions.
GO:0006313   transposition, DNA-mediated  
GO:0004803   transposase activity  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
51 146 4tse (A) 3 345 30.00 0.73 0.11 0.403316 0.49
378 424 1t8z (A) 6 52 2.00 0.98 0 0.144456 -0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132185)

Species Accession Gene Product
Mycobacterium tuberculosis Rv0920c   Probable transposase
Mycobacterium ulcerans MUL_0966   transposase for IS2606
Mycobacterium ulcerans MUL_1147   transposase for IS2606
Mycobacterium ulcerans MUL_3153   transposase for IS2606
Mycobacterium ulcerans MUL_1520   transposase for IS2606
Mycobacterium ulcerans MUL_1030   transposase for IS2606
Mycobacterium ulcerans MUP050   transposase for the insertion element IS2606
Mycobacterium ulcerans MUL_1012   transposase for IS2606
Mycobacterium ulcerans MUL_1406   transposase for IS2606
Mycobacterium ulcerans MUL_3606   transposase for IS2606
Mycobacterium ulcerans MUP026   transposase for the insertion element IS2606
Mycobacterium ulcerans MUL_2983   transposase for IS2606
Mycobacterium ulcerans MUL_4392   transposase for IS2606
Mycobacterium ulcerans MUL_1471   transposase for IS2606
Mycobacterium ulcerans MUL_3229   transposase for IS2606
Mycobacterium ulcerans MUP022   transposase for the insertion element IS2606
Mycobacterium ulcerans MUL_3702   transposase for IS2606
Mycobacterium ulcerans MUL_0974   transposase for IS2606
Mycobacterium ulcerans MUL_4474   transposase for IS2606
Mycobacterium ulcerans MUL_2515   transposase for IS2606
Mycobacterium ulcerans MUL_4613   transposase for IS2606
Mycobacterium ulcerans MUL_1495   transposase for IS2606
Mycobacterium ulcerans MUL_4029   transposase for IS2606
Mycobacterium ulcerans MUP069c   transposase for the insertion element IS2606
Mycobacterium ulcerans MUL_3487   transposase for IS2606
Mycobacterium ulcerans MUL_3061   transposase for IS2606
Mycobacterium ulcerans MUL_2441   transposase for IS2606
Mycobacterium ulcerans MUL_1643   transposase for IS2606
Mycobacterium ulcerans MUL_0163   transposase for IS2606
Mycobacterium ulcerans MUL_4206   transposase for IS2606
Mycobacterium ulcerans MUL_3220   transposase for IS2606
Mycobacterium ulcerans MUL_1267   transposase for IS2606
Mycobacterium ulcerans MUL_1964   transposase for IS2606
Mycobacterium ulcerans MUL_3241   transposase for IS2606
Mycobacterium ulcerans MUL_0598   transposase for IS2606
Mycobacterium ulcerans MUL_5040   transposase for IS2606
Mycobacterium ulcerans MUL_2827   transposase for IS2606
Mycobacterium ulcerans MUL_3418   transposase for IS2606
Mycobacterium ulcerans MUL_3941   transposase for IS2606
Mycobacterium ulcerans MUL_1410   transposase for IS2606
Mycobacterium ulcerans MUL_4606   transposase for IS2606
Mycobacterium ulcerans MUL_2751   transposase for IS2606
Mycobacterium ulcerans MUL_3213   transposase for IS2606
Mycobacterium ulcerans MUL_2404   transposase for IS2606
Mycobacterium ulcerans MUL_1263   transposase for IS2606
Mycobacterium ulcerans MUL_2735   transposase for IS2606
Mycobacterium ulcerans MUL_4727   transposase for IS2606
Mycobacterium ulcerans MUL_0131   transposase for IS2606
Mycobacterium ulcerans MUL_4465   transposase for IS2606
Mycobacterium ulcerans MUL_0601   transposase for IS2606
Mycobacterium ulcerans MUL_4895   transposase for IS2606
Mycobacterium ulcerans MUL_4368   transposase for IS2606
Mycobacterium ulcerans MUL_0575   transposase for IS2606
Mycobacterium ulcerans MUL_0780   transposase for IS2606
Mycobacterium ulcerans MUL_3438   transposase for IS2606
Mycobacterium ulcerans MUL_0025   transposase for IS2606
Mycobacterium ulcerans MUL_1582   transposase for IS2606
Mycobacterium ulcerans MUP055   transposase for the insertion element IS2606
Mycobacterium ulcerans MUL_3224   transposase for IS2606
Mycobacterium ulcerans MUL_2347   transposase for IS2606
Mycobacterium ulcerans MUL_1357   transposase for IS2606
Mycobacterium ulcerans MUL_4584   transposase for IS2606
Mycobacterium ulcerans MUL_2425   transposase for IS2606
Mycobacterium ulcerans MUL_4586   transposase for IS2606
Mycobacterium ulcerans MUL_2913   transposase for IS2606
Mycobacterium ulcerans MUL_2898   transposase for IS2606
Mycobacterium ulcerans MUL_4531   transposase for IS2606
Mycobacterium ulcerans MUL_1849   transposase for IS2606
Mycobacterium ulcerans MUL_3520   transposase for IS2606
Mycobacterium ulcerans MUL_0977   transposase for IS2606
Mycobacterium ulcerans MUL_3833   transposase for IS2606
Mycobacterium ulcerans MUP031c   transposase for the insertion element IS2606
Mycobacterium ulcerans MUL_2219   transposase for IS2606
Mycobacterium ulcerans MUL_4397   transposase for IS2606
Mycobacterium ulcerans MUL_3609   transposase for IS2606
Mycobacterium ulcerans MUL_4214   transposase for IS2606
Mycobacterium ulcerans MUL_2350   transposase for IS2606
Mycobacterium ulcerans MUP036c   transposase for the insertion element IS2606
Mycobacterium ulcerans MUL_3221   transposase for IS2606
Mycobacterium ulcerans MUL_0520   transposase for IS2606
Schistosoma japonicum Sjp_0313180   ko:K07493 putative transposase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_2219 (Mycobacterium ulcerans), transposase for IS2606
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