Detailed view for MUL_1512

Basic information

TDR Targets ID: 952226
Mycobacterium ulcerans, UDP-glucose 4-epimerase
Source Database / ID:  KEGG  

pI: 4.9825 | Length (AA): 339 | MW (Da): 37642 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01370   NAD dependent epimerase/dehydratase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0050662   coenzyme binding  
GO:0003824   catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 333 1gy8 (A) 1 376 25.00 0 1 1.1596 -0.11
1 74 1lss (A) 1 71 18.00 0 0.26 0.392089 -0.71
1 336 5gy7 (A) 1 335 28.00 0 1 1.31445 -0.27
1 320 4zrm (A) 1 294 34.00 0 1 1.20805 0.17
2 339 1i24 (A) 3 376 16.00 0 1 1.09235 0.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130678)

Species Accession Gene Product
Arabidopsis thaliana AT3G23820   UDP-D-glucuronate 4-epimerase 6
Arabidopsis thaliana AT2G45310   UDP-D-glucuronate 4-epimerase 4
Arabidopsis thaliana AT4G12250   UDP-D-glucuronate 4-epimerase 5
Arabidopsis thaliana AT4G30440   UDP-D-glucuronate 4-epimerase 1
Arabidopsis thaliana AT1G02000   UDP-D-glucuronate 4-epimerase 2
Arabidopsis thaliana AT4G00110   UDP-D-glucuronate 4-epimerase 3
Mycobacterium tuberculosis Rv0536   Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase
Mycobacterium ulcerans MUL_0635   UDP-glucose 4-epimerase
Mycobacterium ulcerans MUL_1512   UDP-glucose 4-epimerase
Oryza sativa 4347499   Os09g0504000
Oryza sativa 4346094   Os08g0526100
Oryza sativa 4330975   Os02g0791500
Oryza sativa 4332258   Os03g0249500

Essentiality

MUL_1512 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu544 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_1512 (Mycobacterium ulcerans), UDP-glucose 4-epimerase
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