Detailed view for MUL_3255

Basic information

TDR Targets ID: 953122
Mycobacterium ulcerans, hypothetical protein
Source Database / ID:  KEGG  

pI: 6.4983 | Length (AA): 190 | MW (Da): 21343 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01230   HIT domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 189 3ano (A) 15 194 92.00 0 1 1.87758 -0.61
51 154 4zgl (A) 2 101 18.00 0.000000022 0.42 0.818668 -0.97

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127985)

Species Accession Gene Product
Arabidopsis thaliana AT5G58240   protein FRAGILE HISTIDINE TRIAD
Babesia bovis BBOV_I004910   bis(5'-adenosyl)-triphosphatase, putative
Candida albicans CaO19.7419   Fhit-like orf
Dictyostelium discoideum DDB_G0274257   hypothetical protein
Homo sapiens ENSG00000189283   fragile histidine triad
Leishmania braziliensis LbrM.23.1160   hypothetical protein, conserved
Leishmania donovani LdBPK_231280.1   HIT domain containing protein, putative
Leishmania infantum LinJ.23.1280   hypothetical protein, conserved
Leishmania major LmjF.23.1055   hypothetical protein, conserved
Leishmania mexicana LmxM.23.1055   hypothetical protein, conserved
Mycobacterium leprae ML0455c   Conserved hypothetical protein
Mus musculus ENSMUSG00000060579   fragile histidine triad gene
Mycobacterium tuberculosis Rv2613c   Conserved protein
Mycobacterium ulcerans MUL_3255   hypothetical protein
Neospora caninum NCLIV_010130   Helicase, DEAD/DEAH family protein, related
Neospora caninum NCLIV_047290   BIS(5-nucleosyl)-tetraphosphatase, putative
Oryza sativa 4349630   Os11g0120600
Plasmodium berghei PBANKA_0611900   histidine triad protein, putative
Plasmodium falciparum PF3D7_1436900   histidine triad protein, putative
Plasmodium knowlesi PKNH_0423500   histidine triad protein, putative
Plasmodium vivax PVX_084695   histidine triad protein, putative
Plasmodium yoelii PY07476   fragile histidine triad protein
Saccharomyces cerevisiae YDR305C   Hnt2p
Trypanosoma brucei gambiense Tbg972.8.2660   Bis(5-adenosyl)-triphosphatase, putative
Trypanosoma brucei Tb927.8.2980   Bis(5'-adenosyl)-triphosphatase, putative
Trypanosoma congolense TcIL3000_8_2900   Bis(5'-adenosyl)-triphosphatase, putative
Trypanosoma cruzi TcCLB.509857.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510513.50   hypothetical protein, conserved
Toxoplasma gondii TGME49_225420   histidine triad domain-containing protein
Toxoplasma gondii TGME49_320120   diadenosine tetraphosphatase family protein
Theileria parva TP03_0531   Bis(5'-nucleosyl)-tetraphosphatase (Asymmetrical), putative
Trichomonas vaginalis TVAG_468310   histidine triad (hit) protein, putative

Essentiality

MUL_3255 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.2980 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.2980 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.2980 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.2980 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0611900 Plasmodium berghei Dispensable plasmo
TGME49_320120 Toxoplasma gondii Essentiality uncertain sidik
TGME49_225420 Toxoplasma gondii Essentiality uncertain sidik
TGME49_320120 Toxoplasma gondii Probably non-essential sidik
TGME49_225420 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens fragile histidine triad Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.01235 0.253974 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_3255 (Mycobacterium ulcerans), hypothetical protein
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