Detailed view for MUL_3955

Basic information

TDR Targets ID: 953678
Mycobacterium ulcerans, F0F1 ATP synthase subunit gamma
Source Database / ID:  KEGG  

pI: 5.512 | Length (AA): 304 | MW (Da): 33771 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00231   ATP synthase

Gene Ontology

Mouse over links to read term descriptions.
GO:0046933   hydrogen ion transporting ATP synthase activity, rotational mechanism  
GO:0045261   proton-transporting ATP synthase complex, catalytic core F(1)  
GO:0015986   ATP synthesis coupled proton transport  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 300 1h8e (G) 1 272 38.00 0 1 1.12616 0.88
3 300 5ik2 (G) 2 285 38.00 0 1 1.46506 -0.55
3 300 2jj2 (G) 1 272 43.00 0.000000000076 0.84 0.526163 1.82
25 263 5zwl (G) 24 277 32.00 0 1 1.09898 -0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127077)

Species Accession Gene Product
Arabidopsis thaliana AT2G33040   ATP synthase subunit gamma
Arabidopsis thaliana AT1G15700   ATP synthase gamma chain 2
Arabidopsis thaliana AT4G04640   ATP synthase gamma chain 1
Babesia bovis BBOV_IV005350   ATP synthase F1 gamma subunit, putative
Brugia malayi Bm1_13335   ATP synthase gamma chain, mitochondrial precursor, putative
Candida albicans CaO19.3223   allele is intact
Candida albicans CaO19.10734   likely ATP synthase similar to S. cerevisiae ATP3 (YBR039W) gamma subunit of F1-ATP synthase
Caenorhabditis elegans CELE_Y69A2AR.18   Protein Y69A2AR.18, isoform C
Dictyostelium discoideum DDB_G0292306   ATP synthase gamma chain
Drosophila melanogaster Dmel_CG7610   ATP synthase-gamma chain
Escherichia coli b3733   F1 sector of membrane-bound ATP synthase, gamma subunit
Echinococcus granulosus EgrG_000115600   ATP synthase gamma subunit
Echinococcus multilocularis EmuJ_000115600   ATP synthase gamma subunit
Homo sapiens ENSG00000165629   ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Leishmania braziliensis LbrM.33.0830   ATP synthase F1 subunit gamma protein
Leishmania donovani LdBPK_212140.1   ATP synthase F1 subunit gamma protein, putative
Leishmania infantum LinJ.21.2140   ATP synthase F1 subunit gamma protein, putative
Leishmania major LmjF.21.1770   ATP synthase F1 subunit gamma protein, putative
Leishmania mexicana LmxM.21.1770   ATP synthase F1 subunit gamma protein, putative
Loa Loa (eye worm) LOAG_09256   hypothetical protein
Mycobacterium leprae ML1144   PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG
Mus musculus ENSMUSG00000025781   ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Mycobacterium tuberculosis Rv1309   Probable ATP synthase gamma chain AtpG
Mycobacterium ulcerans MUL_3955   F0F1 ATP synthase subunit gamma
Neospora caninum NCLIV_031920   ATP synthase gama chain, putative
Oryza sativa 4348305   Os10g0320400
Oryza sativa 4343366   Os07g0513000
Onchocerca volvulus OVOC11295   ATP synthase subunit gamma, mitochondrial homolog
Plasmodium berghei PBANKA_1409800   ATP synthase subunit gamma, mitochondrial, putative
Plasmodium falciparum PF3D7_1311300   ATP synthase subunit gamma, mitochondrial
Plasmodium knowlesi PKNH_1411700   ATP synthase subunit gamma, mitochondrial, putative
Plasmodium vivax PVX_122395   ATP synthase subunit gamma, mitochondrial, putative
Plasmodium yoelii PY02803   ATP synthase F1, gamma subunit
Saccharomyces cerevisiae YBR039W   F1F0 ATP synthase subunit gamma
Schistosoma japonicum Sjp_0211820   ko:K02136 F-type H+-transporting ATPase gamma chain, putative
Schistosoma mansoni Smp_033670.1   ATP synthase gamma subunit
Schistosoma mansoni Smp_033670.5   ATP synthase gamma subunit
Schistosoma mansoni Smp_033670.2   ATP synthase gamma subunit
Schistosoma mansoni Smp_033670.3   ATP synthase gamma subunit
Schistosoma mansoni Smp_033670.4   ATP synthase gamma subunit
Schmidtea mediterranea mk4.000187.03   ATP synthase gamma subunit, putative
Trypanosoma brucei gambiense Tbg972.10.90   ATP synthase F1 subunit gamma protein, putative
Trypanosoma brucei Tb927.10.180   ATP synthase F1 subunit gamma protein, putative
Trypanosoma congolense TcIL3000_10_50   ATP synthase F1 subunit gamma protein, putative
Trypanosoma cruzi TcCLB.504069.80   ATP synthase F1 subunit gamma protein, putative
Trypanosoma cruzi TcCLB.511145.60   ATP synthase F1 subunit gamma protein, putative
Toxoplasma gondii TGME49_231910   ATP synthase F1 gamma subunit
Theileria parva TP01_0201   ATP synthase F1, gamma chain, putative
Wolbachia endosymbiont of Brugia malayi Wbm0705   ATP synthase F0F1 subunit gamma

Essentiality

MUL_3955 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1331 Mycobacterium tuberculosis essential nmpdr
Tb927.10.180 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.180 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.180 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.180 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3733 Escherichia coli non-essential goodall
CELE_Y69A2AR.18 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_1409800 Plasmodium berghei Slow plasmo
TGME49_231910 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Probable ATP synthase gamma chain AtpG Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.015 0.3246 0.4157

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier MUL_3955 (Mycobacterium ulcerans), F0F1 ATP synthase subunit gamma
Title for this comment
Comment