pI: 5.6615 |
Length (AA): 511 |
MW (Da): 53775 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 506 | 2rgh (A) | 2 | 576 | 22.00 | 0.000093 | 1 | 1.14927 | 0.33 |
12 | 505 | 2rgo (B) | 4 | 568 | 29.00 | 0 | 1 | 1.24043 | 0.18 |
23 | 496 | 2rgh (A) | 17 | 561 | 32.00 | 0 | 1 | 1.21329 | -0.04 |
25 | 54 | 2ywl (A) | 2 | 31 | 43.00 | 0.43 | 0.4 | 0.435508 | 0.37 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127215)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G10370 | glycerol-3-phosphate dehydrogenase SDP6 |
Babesia bovis | BBOV_III000930 | FAD-dependent glycerol-3-phosphate dehydrogenase, putative |
Candida albicans | CaO19.10645 | glycerol-3-phosphate dehydrogenase, mitochondrial |
Candida albicans | CaO19.3133 | glycerol-3-phosphate dehydrogenase, mitochondrial |
Caenorhabditis elegans | CELE_T25G3.4 | Protein T25G3.4 |
Dictyostelium discoideum | DDB_G0283951 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8256 | Glycerophosphate oxidase-1 |
Drosophila melanogaster | Dmel_CG2137 | CG2137 gene product from transcript CG2137-RA |
Escherichia coli | b3426 | sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding |
Escherichia coli | b2241 | sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding |
Echinococcus granulosus | EgrG_000964600 | glycerol 3 phosphate dehydrogenase |
Echinococcus multilocularis | EmuJ_000964600 | glycerol 3 phosphate dehydrogenase |
Homo sapiens | ENSG00000115159 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) |
Leishmania braziliensis | LbrM.28.0250 | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial |
Leishmania donovani | LdBPK_280240.1 | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial |
Leishmania infantum | LinJ.28.0240 | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial |
Leishmania mexicana | LmxM.28.0240 | glycerol-3-phosphate dehydrogenase, putative |
Loa Loa (eye worm) | LOAG_11054 | glycerol-3-phosphate dehydrogenase |
Loa Loa (eye worm) | LOAG_08286 | hypothetical protein |
Mycobacterium leprae | ML0713 | Probable glycerol-3-phosphate dehydrogenase GlpD |
Mus musculus | ENSMUSG00000026827 | glycerol phosphate dehydrogenase 2, mitochondrial |
Mycobacterium tuberculosis | Rv3302c | Probable glycerol-3-phosphate dehydrogenase GlpD2 |
Mycobacterium tuberculosis | Rv2249c | Probable glycerol-3-phosphate dehydrogenase GlpD1 |
Mycobacterium ulcerans | MUL_2667 | glycerol-3-phosphate dehydrogenase GlpD2 |
Mycobacterium ulcerans | MUL_1300 | glycerol-3-phosphate dehydrogenase |
Neospora caninum | NCLIV_024220 | glycerol-3-phosphate dehydrogenase, putative |
Oryza sativa | 4335210 | Os04g0224900 |
Plasmodium berghei | PBANKA_0404800 | FAD-dependent glycerol-3-phosphate dehydrogenase, putative |
Plasmodium falciparum | PF3D7_0306400 | FAD-dependent glycerol-3-phosphate dehydrogenase, putative |
Plasmodium knowlesi | PKNH_0836300 | FAD-dependent glycerol-3-phosphate dehydrogenase, putative |
Plasmodium vivax | PVX_119445 | FAD-dependent glycerol-3-phosphate dehydrogenase, putative |
Plasmodium yoelii | PY05303 | putative FAD-dependent glycerol-3-phosphate dehydrogenase |
Saccharomyces cerevisiae | YIL155C | glycerol-3-phosphate dehydrogenase |
Schistosoma japonicum | Sjp_0104060 | Probable glycerol-3-phosphate dehydrogenase, mitochondrial precursor, putative |
Schistosoma japonicum | Sjp_0303310 | ko:K00111 glycerol-3-phosphate dehydrogenase [EC1.1.99.5A], putative |
Schistosoma mansoni | Smp_121990 | glycerol-3-phosphate dehydrogenase |
Schmidtea mediterranea | mk4.017466.00 | |
Schmidtea mediterranea | mk4.018679.00 | Glycerol-3-phosphate dehydrogenase, mitochondrial |
Schmidtea mediterranea | mk4.011430.03 | Glycerol-3-phosphate dehydrogenase, mitochondrial |
Schmidtea mediterranea | mk4.016770.00 | Glycerol-3-phosphate dehydrogenase, mitochondrial |
Schmidtea mediterranea | mk4.011430.04 | Glycerol-3-phosphate dehydrogenase, mitochondrial |
Schmidtea mediterranea | mk4.020831.00 | Glycerol-3-phosphate dehydrogenase, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.11.8440 | glycerol-3-phosphate dehydrogenase, putative |
Trypanosoma brucei | Tb927.11.7380 | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial |
Trypanosoma congolense | TcIL3000.11.7960 | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial |
Trypanosoma congolense | TcIL3000_0_58760 | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial |
Trypanosoma cruzi | TcCLB.511151.90 | glycerol-3-phosphate dehydrogenase, putative |
Toxoplasma gondii | TGME49_263730 | FAD-dependent glycerol-3-phosphate dehydrogenase |
Theileria parva | TP03_0730 | glycerol-3-phosphate dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.5280 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5280 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5280 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.5280 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2241 | Escherichia coli | non-essential | goodall |
b3426 | Escherichia coli | non-essential | goodall |
PBANKA_0404800 | Plasmodium berghei | Slow | plasmo |
TGME49_263730 | Toxoplasma gondii | Probably non-essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.