Detailed view for MUL_0623

Basic information

TDR Targets ID: 955520
Mycobacterium ulcerans, glutamate-1-semialdehyde aminotransferase
Source Database / ID:  KEGG  

pI: 5.381 | Length (AA): 443 | MW (Da): 45741 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00202   Aminotransferase class-III

Gene Ontology

Mouse over links to read term descriptions.
GO:0042286   glutamate-1-semialdehyde 2,1-aminomutase activity  
GO:0030170   pyridoxal phosphate binding  
GO:0008483   transaminase activity  
GO:0003824   catalytic activity  
GO:0033014   tetrapyrrole biosynthetic process  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 435 3k28 (A) 1 428 50.00 0 1 1.60754 -0.61
8 436 3l44 (A) 2 432 39.00 0 1 1.4228 -0.16
8 436 3bs8 (A) 1 429 50.00 0 1 1.6178 -0.59
11 435 5i92 (A) 1 427 51.00 0 1 1.59377 -0.44
13 430 2e7u (A) 5 423 53.00 0 1 1.58727 -0.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129427)

Species Accession Gene Product
Arabidopsis thaliana AT3G48730   glutamate-1-semialdehyde 2,1-aminomutase 2
Arabidopsis thaliana AT5G63570   glutamate-1-semialdehyde-2,1-aminomutase
Chlamydia trachomatis CT_210   glutamate-1-semialdehyde-2,1-aminomutase
Escherichia coli b0154   glutamate-1-semialdehyde aminotransferase (aminomutase)
Mycobacterium leprae ML2414c   PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)
Mycobacterium tuberculosis Rv0524   Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)
Mycobacterium ulcerans MUL_0623   glutamate-1-semialdehyde aminotransferase
Oryza sativa 4346136   Os08g0532200
Schmidtea mediterranea mk4.057167.00  

Essentiality

MUL_0623 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu532 Mycobacterium tuberculosis essential nmpdr
b0154 Escherichia coli essential goodall
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_0623 (Mycobacterium ulcerans), glutamate-1-semialdehyde aminotransferase
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