Detailed view for EmuJ_000658150

Basic information

TDR Targets ID: 956255
Echinococcus multilocularis, cubilin

Source Database / ID:  GeneDB

pI: 6.9867 | Length (AA): 1159 | MW (Da): 128303 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00431   CUB domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
255 376 1spp (B) 2 109 20.00 0 0.25 0.104663 -0.44
262 378 2wno (A) 141 248 25.00 0 0.53 0.384349 -0.83
265 396 2qqm (A) 156 282 33.00 0.00037 0.32 0.294791 0.5
269 376 1sfp (A) 18 110 24.00 0 0.82 0.272584 -0.37
779 884 4gza (H) 32 136 28.00 0.0022 0.83 0.405358 -0.02
780 884 2qqk (A) 34 137 35.00 0.000052 0.98 0.446495 0.01
891 943 3ojy (B) 61 102 50.00 0.00034 0.78 0.327629 0.25
1081 1124 1jvr (A) 88 119 53.00 0.72 0.51 0.166864 0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138356)

Species Accession Gene Product
Caenorhabditis elegans lev-10   Protein LEV-10, isoform A
Drosophila melanogaster Dmel_CG42613   CG42613 gene product from transcript CG42613-RE
Echinococcus granulosus EgrG_000658150   cubilin
Echinococcus multilocularis EmuJ_000658150   cubilin
Loa Loa (eye worm) LOAG_11774   hypothetical protein
Schistosoma japonicum Sjp_0118140   IPR000859,CUB,domain-containing
Schistosoma japonicum Sjp_0111900   IPR000859,CUB,domain-containing
Schistosoma mansoni Smp_132930   hypothetical protein
Schmidtea mediterranea mk4.003730.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0152 0.3381 0.5626
0.0139 0.3164 0.5315
0.0034 0.3155 0.4933
0.0124 0.3617 0.5815

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EmuJ_000658150 (Echinococcus multilocularis), cubilin
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