Detailed view for EmuJ_000315000

Basic information

TDR Targets ID: 956949
Echinococcus multilocularis,
Source Database / ID:  GeneDB

pI: 8.7655 | Length (AA): 1024 | MW (Da): 115409 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03200   Glycosyl hydrolase family 63 C-terminal domain
PF16923   Glycosyl hydrolase family 63 N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004573   mannosyl-oligosaccharide glucosidase activity  
GO:0003824   catalytic activity  
GO:0009311   oligosaccharide metabolic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
174 988 5mhf (C) 59 834 39.00 0 1 1.2031 -0.32
182 987 5mhf (A) 67 833 46.00 0 1 1.21881 -0.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129620)

Species Accession Gene Product
Arabidopsis thaliana AT1G67490   alpha-glucosidase I
Arabidopsis thaliana AT1G24320   alpha-glucosidase 2
Brugia malayi Bm1_40265   Mannosyl oligosaccharide glucosidase family protein
Candida albicans CaO19.4719   similar to C terminus of S. cerevisiae CWH41 (YGL027C) glucosidase I
Candida albicans CaO19.4421   similar to N terminus of S. cerevisiae CWH41 (YGL027C) glucosidase I
Candida albicans CaO19.11899   similar to N terminus of S. cerevisiae CWH41 (YGL027C) glucosidase I
Caenorhabditis elegans CELE_F13H10.4   Protein F13H10.4, isoform B
Dictyostelium discoideum DDB_G0280145   glycoside hydrolase family 63 protein
Drosophila melanogaster Dmel_CG1597   CG1597 gene product from transcript CG1597-RB
Echinococcus granulosus EgrG_000315000   mannosyl oligosaccharide glucosidase
Echinococcus multilocularis EmuJ_000315000  
Homo sapiens ENSG00000115275   mannosyl-oligosaccharide glucosidase
Leishmania braziliensis LbrM.28.2400   hypothetical protein, conserved
Leishmania donovani LdBPK_282350.1   Mannosyl oligosaccharide glucosidase, putative
Leishmania infantum LinJ.28.2350   hypothetical protein, conserved
Leishmania major LmjF.28.2200   hypothetical protein, conserved
Leishmania mexicana LmxM.28.2200   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_03690   mannosyl oligosaccharide glucosidase
Mus musculus ENSMUSG00000030036   mannosyl-oligosaccharide glucosidase
Oryza sativa 4327748   Os01g0921200
Saccharomyces cerevisiae YGL027C   Cwh41p
Schistosoma japonicum Sjp_0310110   ko:K01228 mannosyl-oligosaccharide glucosidase [EC3.2.1.106], putative
Schistosoma japonicum Sjp_0314810   ko:K01228 mannosyl-oligosaccharide glucosidase [EC3.2.1.106], putative
Schistosoma japonicum Sjp_0060890   Mannosyl-oligosaccharide glucosidase, putative
Schistosoma japonicum Sjp_0060870   Mannosyl-oligosaccharide glucosidase, putative
Schistosoma mansoni Smp_024580.2   mannosyl-oligosaccharide glucosidase
Schistosoma mansoni Smp_024580.1   mannosyl-oligosaccharide glucosidase
Schmidtea mediterranea mk4.005350.04  
Schmidtea mediterranea mk4.010495.00  
Trypanosoma cruzi TcCLB.511805.10   mannosyl-oligosaccharide glucosidase, putative
Trypanosoma cruzi TcCLB.509201.10   hypothetical protein, conserved

Essentiality

EmuJ_000315000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F13H10.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000315000 (Echinococcus multilocularis),
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