Detailed view for EmuJ_000947600

Basic information

TDR Targets ID: 957038
Echinococcus multilocularis, leucine rich repeat containing protein 47
Source Database / ID:  GeneDB

pI: 7.2195 | Length (AA): 545 | MW (Da): 60062 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13855   Leucine rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 75 4r58 (A) 124 184 31.00 0.018 1 0.536127 -0.56
18 216 4u06 (A) 145 334 39.00 0 1 0.891638 -0.96
28 283 4ow2 (A) 220 443 34.00 0.00000027 1 0.713225 0.47
36 283 4bv4 (R) 112 372 29.00 0.000000000066 1 0.764546 0.11
43 220 4fmz (A) 190 360 31.00 0.00000000084 1 0.803106 -1.26
63 149 3e6j (A) 72 160 45.00 0.0000000065 1 0.760133 -0.8
66 224 1ozn (A) 83 271 36.00 0.000021 1 0.589243 -0.27
280 508 3l4g (B) 99 292 23.00 0 0.89 0.522583 0.18
305 544 3l4g (B) 119 318 24.00 0 0.99 0.534567 0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133243)

Species Accession Gene Product
Brugia malayi Bm1_45765   Leucine Rich Repeat family protein
Caenorhabditis elegans CELE_Y54E10A.6   Protein Y54E10A.6
Echinococcus granulosus EgrG_000947600   leucine rich repeat containing protein 47
Echinococcus multilocularis EmuJ_000947600   leucine rich repeat containing protein 47
Homo sapiens 57470   leucine rich repeat containing 47
Mus musculus ENSMUSG00000029028   leucine rich repeat containing 47
Onchocerca volvulus OVOC8671  
Schistosoma japonicum Sjp_0002890   Leucine-rich repeat-containing protein 40, putative
Schistosoma japonicum Sjp_0200500   Leucine-rich repeat-containing protein 47, putative
Schistosoma mansoni Smp_063230   hypothetical protein
Schmidtea mediterranea mk4.003470.03  

Essentiality

EmuJ_000947600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y54E10A.6 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000947600 (Echinococcus multilocularis), leucine rich repeat containing protein 47
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