Detailed view for EmuJ_000677910

Basic information

TDR Targets ID: 957194
Echinococcus multilocularis, kelch protein 3
Source Database / ID:  GeneDB

pI: 7.2411 | Length (AA): 829 | MW (Da): 89272 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00651   BTB/POZ domain
PF01344   Kelch motif
PF07707   BTB And C-terminal Kelch

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 152 2mqa (A) 23 140 14.00 0 0.06 0.288859 -0.37
38 102 2kr0 (A) 197 265 31.00 0.037 0.03 0.182508 1.19
253 360 3fkc (A) 12 115 26.00 0 1 0.533177 -1.16
256 446 4hxi (A) 33 223 59.00 0 1 0.918698 -0.18
524 821 2dyh (A) 324 610 40.00 0 1 0.858369 -0.81
525 821 4chb (A) 306 590 58.00 0 1 1.07656 -0.88
777 828 2vpj (A) 429 479 39.00 0.13 0.42 0.380826 0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127232)

Species Accession Gene Product
Caenorhabditis elegans CELE_C47D12.7   Protein KEL-1, isoform B
Drosophila melanogaster Dmel_CG7210   kelch
Echinococcus granulosus EgrG_000361600   kelch protein 3 like
Echinococcus granulosus EgrG_000677910   kelch protein 3
Echinococcus multilocularis EmuJ_000677910   kelch protein 3
Echinococcus multilocularis EmuJ_000361700   Galactose oxidase kelch, beta propeller
Homo sapiens ENSG00000109466   kelch-like family member 2
Homo sapiens ENSG00000146021   kelch-like family member 3
Mus musculus ENSMUSG00000031605   kelch-like 2, Mayven
Mus musculus ENSMUSG00000014164   kelch-like 3
Schistosoma japonicum Sjp_0316980   Kelch-like protein 3, putative
Schistosoma japonicum Sjp_0214320   expressed protein
Schistosoma japonicum Sjp_0047890   Ring canal kelch homolog, putative
Schistosoma mansoni Smp_141890   hypothetical protein
Schmidtea mediterranea mk4.019201.00   Kelch-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000677910 (Echinococcus multilocularis), kelch protein 3
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