pI: 5.5896 |
Length (AA): 5216 |
MW (Da): 579537 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 16 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
12 | 1283 | 3vkg (A) | 1967 | 3180 | 14.00 | 0 | 0.9 | 0.082765 | 1.57 |
473 | 1306 | 4akg (A) | 1808 | 2589 | 17.00 | 0 | 1 | 0.0489926 | 1.23 |
765 | 1906 | 3vkh (A) | 1945 | 3051 | 20.00 | 0 | 1 | 0.129042 | 1.22 |
774 | 978 | 5c3c (A) | 19 | 209 | 24.00 | 0 | 1 | 0.165202 | -0.3 |
790 | 972 | 5c3c (A) | 34 | 203 | 30.00 | 0.00000097 | 1 | 0.212884 | 0.04 |
860 | 2026 | 3vkg (A) | 2012 | 3155 | 24.00 | 0.0039 | 1 | 0.199535 | 1.26 |
1527 | 1643 | 1r6b (X) | 467 | 583 | 32.00 | 0.55 | 0.53 | 0.163231 | 1.04 |
1550 | 1732 | 2r44 (A) | 48 | 209 | 31.00 | 0.0000026 | 0.97 | 0.245884 | 0.48 |
3338 | 4175 | 3icq (T) | 48 | 892 | 11.00 | 0 | 0.77 | 0.17376 | 0.59 |
3367 | 4261 | 4oo8 (D) | 181 | 1307 | 9.00 | 0.71 | 0.03 | -0.103513 | 2.34 |
3424 | 4182 | 4bsm (A) | 139 | 957 | 11.00 | 0 | 0.55 | 0.0676138 | 1.08 |
3480 | 4266 | 5me3 (A) | 484 | 1374 | 12.00 | 0 | 0.87 | 0.119982 | 0.8 |
3483 | 4335 | 2x19 (B) | 31 | 947 | 12.00 | 0 | 1 | 0.197635 | 0.44 |
3667 | 4557 | 1tr2 (A) | 132 | 1026 | 12.00 | 0 | 1 | 0.162921 | 0.73 |
3897 | 4078 | 5vjt (A) | 4 | 192 | 14.00 | 0.00037 | 0.91 | 0.290793 | -1.19 |
4998 | 5194 | 1ido (A) | 135 | 315 | 17.00 | 0 | 1 | 0.198868 | -0.49 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127263)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G67120 | protein MIDASIN1 |
Babesia bovis | BBOV_III002250 | ATPase associated with various cellular activities (AAA) family protein |
Brugia malayi | Bm1_25520 | hypothetical protein |
Candida albicans | CaO19.12167 | similar to S. cerevisiae YLR106C |
Candida albicans | CaO19.12161 | similar to N terminus of midasin-like orf |
Candida albicans | CaO19.4697 | similar to midasin, highly conserved, putative nuclear chaperone |
Caenorhabditis elegans | CELE_F55F10.1 | Protein F55F10.1, isoform B |
Cryptosporidium hominis | Chro.50062 | hypothetical protein |
Cryptosporidium parvum | cgd5_3110 | MDN1, midasin |
Dictyostelium discoideum | DDB_G0295765 | type A von Willebrand factor domain-containing protein |
Drosophila melanogaster | Dmel_CG13185 | CG13185 gene product from transcript CG13185-RD |
Echinococcus granulosus | EgrG_000061900 | hypothetical protein |
Echinococcus granulosus | EgrG_000887300 | midasin |
Entamoeba histolytica | EHI_153780 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000887300 | midasin |
Giardia lamblia | GL50803_39312 | Midasin |
Homo sapiens | ENSG00000112159 | MDN1, midasin homolog (yeast) |
Leishmania braziliensis | LbrM.20.4470 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.20.4460 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_200280.1 | Midasin, putative |
Leishmania infantum | LinJ.20.0280 | hypothetical protein, conserved |
Leishmania major | LmjF.20.0260 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.20.0260 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_14100 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15966 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06453 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15940 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06452 | hypothetical protein |
Loa Loa (eye worm) | LOAG_16062 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15992 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10210 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02751 | serine/threonine protein kinase |
Loa Loa (eye worm) | LOAG_15860 | hypothetical protein |
Mus musculus | ENSMUSG00000058006 | midasin homolog (yeast) |
Neospora caninum | NCLIV_017650 | hypothetical protein |
Oryza sativa | 4348797 | Os10g0456900 |
Onchocerca volvulus | OVOC12265 | Midasin homolog |
Plasmodium berghei | PBANKA_1010300 | dynein-related AAA-type ATPase, putative |
Plasmodium falciparum | PF3D7_1434500 | dynein-related AAA-type ATPase, putative |
Plasmodium knowlesi | PKNH_0421100 | dynein-related AAA-type ATPase, putative |
Plasmodium vivax | PVX_084810 | dynein-related AAA-type ATPase, putative |
Plasmodium yoelii | PY03141 | dentin sialophosphoprotein precursor |
Plasmodium yoelii | PY00634 | hypothetical protein |
Plasmodium yoelii | PY03140 | Drosophila melanogaster SD07158p-related |
Saccharomyces cerevisiae | YLR106C | AAA family ATPase midasin |
Schistosoma japonicum | Sjp_0305860 | Midasin, putative |
Schistosoma japonicum | Sjp_0008510 | Midasin, putative |
Schistosoma japonicum | Sjp_0008500 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
Schistosoma japonicum | Sjp_0113040 | Midasin, putative |
Schistosoma japonicum | Sjp_0135260 | expressed protein |
Schistosoma mansoni | Smp_143650 | midasin (midas-containing protein) |
Schistosoma mansoni | Smp_143660 | mdn1 midasin-related |
Schmidtea mediterranea | mk4.037686.01 | |
Schmidtea mediterranea | mk4.037686.00 | Midasin |
Schmidtea mediterranea | mk4.003346.00 | Midasin |
Schmidtea mediterranea | mk4.003346.02 | |
Schmidtea mediterranea | mk4.004262.01 | |
Trypanosoma brucei gambiense | Tbg972.1.290 | hypothetical protein, conserved |
Trypanosoma brucei | Tb11.v5.0419 | AAA domain (dynein-related subfamily), putative |
Trypanosoma brucei | Tb927.1.880 | Midasin, putative |
Trypanosoma brucei | Tb11.v5.0418 | AAA domain (dynein-related subfamily), putative |
Trypanosoma congolense | TcIL3000_1_370 | Midasin, putative |
Toxoplasma gondii | TGME49_242625 | ATPase family associated with various cellular activities (AAA) subfamily protein |
Theileria parva | TP03_0590 | hypothetical protein |
Theileria parva | TP03_0591 | hypothetical protein |
Trichomonas vaginalis | TVAG_243360 | midasin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.880 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.880 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.880 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.880 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F55F10.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F55F10.1 | Caenorhabditis elegans | slow growth | wormbase |
YLR106C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1010300 | Plasmodium berghei | Essential | plasmo |
TGME49_242625 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.