Detailed view for EmuJ_000871200

Basic information

TDR Targets ID: 957656
Echinococcus multilocularis, choline phosphate cytidylyltransferase B
Source Database / ID:  GeneDB

pI: 8.6044 | Length (AA): 368 | MW (Da): 41773 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01467   Cytidylyltransferase-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  
GO:0009058   biosynthetic process  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 288 4mvc (A) 41 295 57.00 0 1 0.989865 0.87
38 287 4mvd (B) 41 294 52.00 0 1 1.08965 1.13
74 210 3elb (A) 20 154 41.00 0.0000021 1 0.931083 -0.64
75 216 4zct (A) 616 775 56.00 0 1 1.00417 -0.25
77 198 2b7l (A) 2 115 25.00 0.011 0.99 0.672322 -0.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128351)

Species Accession Gene Product
Arabidopsis thaliana AT2G32260   phosphorylcholine cytidylyltransferase
Arabidopsis thaliana AT4G15130   phosphorylcholine cytidylyltransferase2
Babesia bovis BBOV_II005220   choline-phosphate cytidylyltransferase
Brugia malayi Bm1_32595   Putative choline-phosphate cytidylyltransferase, putative
Candida albicans CaO19.11663   phosphorylcholine transferase
Candida albicans CaO19.4186   phosphorylcholine transferase
Caenorhabditis elegans CELE_F08C6.2   Protein PCYT-1, isoform B
Cryptosporidium hominis Chro.80135   cholinephosphate cytidylyltransferase
Cryptosporidium parvum cgd8_1150   choline-phosphate cytidylyltransferase
Dictyostelium discoideum DDB_G0290229   cholinephosphate cytidylyltransferase
Drosophila melanogaster Dmel_CG1049   CTP:phosphocholine cytidylyltransferase 1
Drosophila melanogaster Dmel_CG18330   CTP:phosphocholine cytidylyltransferase 2
Echinococcus granulosus EgrG_000871200   choline phosphate cytidylyltransferase B
Echinococcus multilocularis EmuJ_000871200   choline phosphate cytidylyltransferase B
Homo sapiens 5130   phosphate cytidylyltransferase 1, choline, alpha
Homo sapiens ENSG00000102230   phosphate cytidylyltransferase 1, choline, beta
Loa Loa (eye worm) LOAG_05103   cholinephosphate cytidylyl transferase B2
Mus musculus ENSMUSG00000035246   phosphate cytidylyltransferase 1, choline, beta isoform
Mus musculus ENSMUSG00000005615   phosphate cytidylyltransferase 1, choline, alpha isoform
Neospora caninum NCLIV_059380   SJCHGC06128 protein, related
Oryza sativa 4344725   Os08g0161800
Oryza sativa 4349510   Os10g0578900
Oryza sativa 4328455   Os02g0173500
Plasmodium berghei PBANKA_1415100   choline-phosphate cytidylyltransferase
Plasmodium falciparum PF3D7_1316600   choline-phosphate cytidylyltransferase
Plasmodium knowlesi PKNH_1417300   choline-phosphate cytidylyltransferase, putative
Plasmodium vivax PVX_122650   choline-phosphate cytidylyltransferase, putative
Plasmodium yoelii PY02436   cholinephosphate cytidylyltransferase
Saccharomyces cerevisiae YGR202C   choline-phosphate cytidylyltransferase
Schistosoma japonicum Sjp_0016680   ko:K00968 choline-phosphate cytidylyltransferase [EC2.7.7.15], putative
Schistosoma japonicum Sjp_0016660   expressed protein
Schistosoma mansoni Smp_124730   choline-phosphate cytidylyltransferase
Schmidtea mediterranea mk4.010240.00  
Schmidtea mediterranea mk4.026732.01  
Schmidtea mediterranea mk4.007939.00  
Schmidtea mediterranea mk4.031403.00  
Toxoplasma gondii TGME49_216930   cholinephosphate cytidylyltransferase
Theileria parva TP02_0826   cholinephosphate cytidylyltransferase, putative

Essentiality

EmuJ_000871200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F08C6.2 Caenorhabditis elegans larval arrest wormbase
CELE_F08C6.2 Caenorhabditis elegans slow growth wormbase
PBANKA_1415100 Plasmodium berghei Essential plasmo
TGME49_216930 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000871200 (Echinococcus multilocularis), choline phosphate cytidylyltransferase B
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