Detailed view for EmuJ_001057100

Basic information

TDR Targets ID: 957913
Echinococcus multilocularis, heterogeneous nuclear ribonucleoprotein l
Source Database / ID:  GeneDB

pI: 8.8436 | Length (AA): 582 | MW (Da): 64695 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF13893   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0003723   RNA binding  
GO:0003676   nucleic acid binding  
GO:0006397   mRNA processing  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 42 2cq0 (A) 225 263 36.00 0.27 0.09 0.385847 -0.21
4 42 5ifm (A) 60 98 28.00 0.2 0.03 0.36141 -0.36
12 90 2ytc (A) 233 310 22.00 0 0.99 0.649339 -2.19
16 71 2aym (A) 7 66 36.00 0.025 0.89 0.58072 -1.12
108 214 2mqm (A) 181 287 56.00 0 1 0.945449 -1.13
293 498 4qpt (A) 376 582 34.00 0 1 0.851652 -0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132117)

Species Accession Gene Product
Brugia malayi Bm1_10250   RNA binding protein
Brugia malayi Bm1_23505   hypothetical protein
Brugia malayi Bm1_23500   hypothetical protein
Brugia malayi Bm1_10255   hypothetical protein
Caenorhabditis elegans CELE_C44B7.2   Protein C44B7.2, isoform A
Dictyostelium discoideum DDB_G0275365   hypothetical protein
Drosophila melanogaster Dmel_CG9218   smooth
Echinococcus granulosus EgrG_001057100   heterogeneous nuclear ribonucleoprotein l
Echinococcus multilocularis EmuJ_001057100   heterogeneous nuclear ribonucleoprotein l
Homo sapiens ENSG00000104824   heterogeneous nuclear ribonucleoprotein L
Loa Loa (eye worm) LOAG_04600   hypothetical protein
Loa Loa (eye worm) LOAG_13303   hypothetical protein
Mus musculus ENSMUSG00000015165   heterogeneous nuclear ribonucleoprotein L
Onchocerca volvulus OVOC13436  
Plasmodium yoelii PY01521   hypothetical protein
Schistosoma japonicum Sjp_0204940   Heterogeneous nuclear ribonucleoprotein L, putative
Schistosoma japonicum Sjp_0027700   Heterogeneous nuclear ribonucleoprotein L, putative
Schistosoma mansoni Smp_149700   heterogeneous nuclear ribonucleoprotein
Schistosoma mansoni Smp_051530   heterogeneous nuclear ribonucleoprotein
Schmidtea mediterranea mk4.007783.00   FI03683p

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001057100 (Echinococcus multilocularis), heterogeneous nuclear ribonucleoprotein l
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