Detailed view for EmuJ_001200500

Basic information

TDR Targets ID: 958463
Echinococcus multilocularis, Ribosomal protein L37, mitochondrial
Source Database / ID:  GeneDB

pI: 10.2123 | Length (AA): 145 | MW (Da): 17282 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08561   Mitochondrial ribosomal protein L37

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133101)

Species Accession Gene Product
Arabidopsis thaliana AT3G01740   mitochondrial ribosomal protein L37
Arabidopsis thaliana AT5G14290   mitochondrial ribosomal protein L37
Brugia malayi Bm1_07885   SD09147p
Caenorhabditis elegans CELE_F25H5.6   Protein MRPL-54
Drosophila melanogaster Dmel_CG9353   mitochondrial ribosomal protein L54
Echinococcus granulosus EgrG_001200500   Ribosomal protein L37 mitochondrial
Echinococcus multilocularis EmuJ_001200500   Ribosomal protein L37, mitochondrial
Homo sapiens ENSG00000183617   mitochondrial ribosomal protein L54
Loa Loa (eye worm) LOAG_09268   hypothetical protein
Mus musculus ENSMUSG00000034932   mitochondrial ribosomal protein L54
Oryza sativa 4351876   Os12g0244200
Schistosoma japonicum Sjp_0042200   IPR013870,Ribosomal protein L37, mitochondrial,domain-containing
Schistosoma mansoni Smp_174620   hypothetical protein

Essentiality

EmuJ_001200500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F25H5.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F25H5.6 Caenorhabditis elegans larval arrest wormbase
CELE_F25H5.6 Caenorhabditis elegans slow growth wormbase
CELE_F25H5.6 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001200500 (Echinococcus multilocularis), Ribosomal protein L37, mitochondrial
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