Detailed view for EmuJ_000727300

Basic information

TDR Targets ID: 958528
Echinococcus multilocularis, Alkaline phosphatase, core domain
Source Database / ID:  GeneDB

pI: 8.9116 | Length (AA): 763 | MW (Da): 86470 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01663   Type I phosphodiesterase / nucleotide pyrophosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0051377   mannose-ethanolamine phosphotransferase activity  
GO:0005789   endoplasmic reticulum membrane  
GO:0016021   integral to membrane  
GO:0003824   catalytic activity  
GO:0016740   transferase activity  
GO:0008152   metabolic process  
GO:0006506   GPI anchor biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
48 408 1auk (A) 19 463 10.00 0.00000052 0.1 0.226532 0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130038)

Species Accession Gene Product
Arabidopsis thaliana AT3G01380   sulfatase and phosphatidylinositolglycan class N domain-containing protein
Brugia malayi Bm1_07540   hypothetical protein
Candida albicans CaO19.5244   morphogenesis checkpoint dependent
Candida albicans CaO19.12709   morphogenesis checkpoint dependent
Caenorhabditis elegans CELE_Y54E10BR.1   Protein Y54E10BR.1, isoform A
Dictyostelium discoideum DDB_G0279313   phosphatidylinositol glycan, class N
Drosophila melanogaster Dmel_CG2292   CG2292 gene product from transcript CG2292-RA
Echinococcus multilocularis EmuJ_000727300   Alkaline phosphatase, core domain
Echinococcus multilocularis EmuJ_000573800   gpi ethanolamine phosphate transferase 1
Homo sapiens ENSG00000197563   phosphatidylinositol glycan anchor biosynthesis, class N
Loa Loa (eye worm) LOAG_08601   hypothetical protein
Mus musculus ENSMUSG00000056536   phosphatidylinositol glycan anchor biosynthesis, class N
Oryza sativa 4329782   Os02g0581000
Onchocerca volvulus OVOC4131   GPI ethanolamine phosphate transferase 1 homolog
Saccharomyces cerevisiae YKL165C   Mcd4p
Schistosoma japonicum Sjp_0017570   GPI ethanolamine phosphate transferase 1, putative
Schistosoma japonicum Sjp_0017550   ko:K05285 phosphatidylinositol glycan, class N, putative
Schistosoma japonicum Sjp_0017560   ko:K05285 phosphatidylinositol glycan, class N, putative
Schistosoma mansoni Smp_065130.2   hypothetical protein
Schistosoma mansoni Smp_065130.1   hypothetical protein
Schmidtea mediterranea mk4.000878.00  

Essentiality

EmuJ_000727300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y54E10BR.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y54E10BR.1 Caenorhabditis elegans larval arrest wormbase
YKL165C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000727300 (Echinococcus multilocularis), Alkaline phosphatase, core domain
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