Detailed view for EmuJ_000790700

Basic information

TDR Targets ID: 958856
Echinococcus multilocularis, Ras associated and pleckstrin y
Source Database / ID:  GeneDB

pI: 7.0566 | Length (AA): 735 | MW (Da): 81512 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0007165   signal transduction  

Metabolic Pathways

Rap1 signaling pathway (KEGG)
Platelet activation (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 106 1jvr (A) 8 89 16.00 0 0.14 0.306844 -0.73
337 399 2eth (A) 42 105 38.00 0.41 0.56 0.432714 -0.02
361 622 4gmv (A) 260 519 30.00 0 1 0.692463 -0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132886)

Species Accession Gene Product
Brugia malayi Bm1_04005   PH domain containing protein
Caenorhabditis elegans CELE_F10E9.6   Protein MIG-10, isoform B
Drosophila melanogaster Dmel_CG11940   CG11940 gene product from transcript CG11940-RB
Echinococcus granulosus EgrG_000790700   Ras associated and pleckstrin y
Echinococcus granulosus EgrG_001010600   growth factor receptor bound protein
Echinococcus multilocularis EmuJ_000790700   Ras associated and pleckstrin y
Echinococcus multilocularis EmuJ_001010600   growth factor receptor bound protein
Homo sapiens ENSG00000173166   Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Loa Loa (eye worm) LOAG_07428   hypothetical protein
Loa Loa (eye worm) LOAG_12198   hypothetical protein
Mus musculus ENSMUSG00000026014   Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Onchocerca volvulus OVOC9226   Abnormal cell migration protein 10 homolog
Schistosoma japonicum Sjp_0101380   expressed protein
Schistosoma japonicum Sjp_0082270   expressed protein
Schistosoma japonicum Sjp_0310760   Ras-associated and pleckstrin homology domains-containing protein 1, putative
Schistosoma japonicum Sjp_0082280   expressed protein
Schistosoma japonicum Sjp_0055530   expressed protein
Schistosoma mansoni Smp_052250   growth factor receptor-bound protein
Schistosoma mansoni Smp_156390   growth factor receptor-bound protein
Schmidtea mediterranea mk4.011201.00   Abnormal cell migration protein 10
Schmidtea mediterranea mk4.000597.04   Abnormal cell migration protein 10

Essentiality

EmuJ_000790700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F10E9.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F10E9.6 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000790700 (Echinococcus multilocularis), Ras associated and pleckstrin y
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