Detailed view for EmuJ_001095200

Basic information

TDR Targets ID: 959020
Echinococcus multilocularis, type II inositol 3,4 bisphosphate 4 phosphatase
Source Database / ID:  GeneDB

pI: 6.7924 | Length (AA): 1006 | MW (Da): 112463 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 124 2p0d (A) 326 438 17.00 0 0.59 0.221474 0.1
20 118 5mr1 (A) 45 138 31.00 0.015 1 0.44961 0.01
450 523 4nmx (A) 67 137 37.00 0.37 0.52 0.204759 0.53
508 635 2id6 (A) 54 187 20.00 0 0.5 0.374337 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130363)

Species Accession Gene Product
Brugia malayi Bm1_46610   protein R01H10.7
Caenorhabditis elegans CELE_R01H10.7   Protein R01H10.7
Drosophila melanogaster Dmel_CG42271   CG42271 gene product from transcript CG42271-RC
Echinococcus granulosus EgrG_001095200   type II inositol 34 bisphosphate 4 phosphatase
Echinococcus multilocularis EmuJ_001095200   type II inositol 3,4 bisphosphate 4 phosphatase
Homo sapiens ENSG00000109452   inositol polyphosphate-4-phosphatase, type II, 105kDa
Homo sapiens ENSG00000040933   inositol polyphosphate-4-phosphatase, type I, 107kDa
Loa Loa (eye worm) LOAG_04735   hypothetical protein
Mus musculus ENSMUSG00000037940   inositol polyphosphate-4-phosphatase, type II
Mus musculus ENSMUSG00000026113   inositol polyphosphate-4-phosphatase, type I
Schistosoma japonicum Sjp_0132070   ko:K01109 inositol polyphosphate-4-phosphatase [EC3.1.3.66], putative
Schistosoma japonicum Sjp_0072780   IPR001849,Pleckstrin-like;IPR008614,Acidic fibroblast growth factor binding;IPR000583,Glutamine amidotransferase, class-II;IPR00
Schistosoma japonicum Sjp_0313250   ko:K01109 inositol polyphosphate-4-phosphatase [EC3.1.3.66], putative
Schistosoma japonicum Sjp_0132080   expressed protein
Schistosoma mansoni Smp_081260   hypothetical protein
Schmidtea mediterranea mk4.007532.01  
Schmidtea mediterranea mk4.014259.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001095200 (Echinococcus multilocularis), type II inositol 3,4 bisphosphate 4 phosphatase
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