Detailed view for EmuJ_000105000

Basic information

TDR Targets ID: 959100
Echinococcus multilocularis, mixed lineage leukemia protein mll
Source Database / ID:  GeneDB

pI: 9.6389 | Length (AA): 1617 | MW (Da): 181108 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF00856   SET domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0042800   histone lysine N-methyltransferase activity (H3-K4 specific)  
GO:0003676   nucleic acid binding  
GO:0005515   protein binding  

Metabolic Pathways

Lysine degradation (KEGG)

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 82 3s8s (A) 113 192 34.00 0.000000031 0.96 0.431211 0.22
2 52 1x5t (A) 26 77 20.00 0.031 0.68 0.17834 0.41
2 46 4c7q (A) 26 70 24.00 0.00025 0.84 0.286629 -0.05
2 46 4f25 (A) 119 161 30.00 0.0083 0.99 0.290629 0.26
460 574 2mqa (A) 25 139 13.00 0 0 0.165319 -0.34
1429 1617 6cen (A) 1096 1285 24.00 0.069 1 0.333683 0.53
1451 1617 2w5y (A) 3801 3969 50.00 0 1 0.557478 0.33
1476 1616 4z4p (A) 5395 5536 48.00 0 1 0.593399 -0.17
1477 1600 5hyn (A) 611 732 42.00 0 1 0.580185 -0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_144689)

Species Accession Gene Product
Brugia malayi Bm1_45225   Protein set-2.
Echinococcus granulosus EgrG_000105000   mixed lineage leukemia protein mll
Echinococcus multilocularis EmuJ_000105000   mixed lineage leukemia protein mll
Loa Loa (eye worm) LOAG_01476   hypothetical protein
Schistosoma japonicum Sjp_0051150   ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative
Schistosoma japonicum Sjp_0051140   IPR000637,HMG-I and HMG-Y, DNA-binding,domain-containing
Schistosoma japonicum Sjp_0013360   ATP-dependent RNA helicase DDX3Y, putative
Schistosoma mansoni Smp_140390.3   mixed-lineage leukemia protein mll
Schistosoma mansoni Smp_140390.2   mixed-lineage leukemia protein mll
Schmidtea mediterranea mk4.001072.07  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000105000 (Echinococcus multilocularis), mixed lineage leukemia protein mll
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