Detailed view for EmuJ_000527600

Basic information

TDR Targets ID: 960147
Echinococcus multilocularis, eukaryotic translation initiation factor 2 alpha
Source Database / ID:  GeneDB

pI: 7.0238 | Length (AA): 2136 | MW (Da): 237594 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF05773   RWD domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Structural information

Modbase 3D models:

There are 17 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 142 2daw (A) 8 141 20.00 0 0.43 0.147079 -0.24
2 150 2dmf (A) 3 133 21.00 0 0.82 0.209357 -0.34
2 145 2dax (A) 3 142 20.00 0 0.67 0.219016 -0.51
186 531 3i6u (A) 127 452 16.00 0 0.71 0.080685 0.72
277 531 3c0g (B) 9 244 15.00 0 0.2 0.054082 0.55
386 556 6fd3 (A) 354 535 29.00 0.000000057 1 0.368156 -0.62
392 555 4usf (A) 111 292 27.00 0.0000076 1 0.298879 -0.86
403 555 3aln (A) 203 367 33.00 0.00032 1 0.0987292 0.49
595 1065 4x7k (A) 587 1081 40.00 0 1 -0.393394 1.6
761 1102 5kkt (A) 95 386 22.00 0 0.83 0.0378124 1.05
798 883 5wnl (A) 68 165 42.00 0.0016 1 0.448362 -0.82
816 1245 3hx4 (A) 129 482 21.00 0 0.99 0.0300109 1.2
822 1114 5byz (A) 143 373 30.00 0.0000039 0.71 0.0972723 0.47
841 886 3eb0 (A) 146 192 41.00 0.0065 0.84 0.401636 0.6
843 1150 4ysj (A) 133 362 34.00 0.00000064 0.87 -0.223705 1.81
849 886 3tl8 (A) 401 441 61.00 0.013 0.77 0.46289 1.38
1238 1628 4g84 (A) 119 442 19.00 0 0.98 -0.00124757 0.92

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129525)

Species Accession Gene Product
Arabidopsis thaliana AT3G59410   eIF2alpha kinase
Babesia bovis BBOV_II006890   Ser/Thr protein kinase, putative
Brugia malayi Bm1_30605   RWD domain containing protein
Candida albicans CaO19_6913   hypothetical protein
Candida albicans CaO19.6913   likely protein kinase similar to S. cerevisiae GCN2 (YDR283C) eukaryotic initiation factor 2 alpha kinase
Caenorhabditis elegans CELE_Y81G3A.3   Protein GCN-2, isoform B
Dictyostelium discoideum DDB_G0276829   GCN2 subfamily protein kinase
Dictyostelium discoideum DDB_G0272837   GCN2 subfamily protein kinase
Drosophila melanogaster Dmel_CG1609   CG1609 gene product from transcript CG1609-RA
Echinococcus granulosus EgrG_000527600   eukaryotic translation initiation factor 2 alpha
Echinococcus multilocularis EmuJ_000527600   eukaryotic translation initiation factor 2 alpha
Homo sapiens ENSG00000128829   eukaryotic translation initiation factor 2 alpha kinase 4
Loa Loa (eye worm) LOAG_10609   hypothetical protein
Mus musculus ENSMUSG00000005102   eukaryotic translation initiation factor 2 alpha kinase 4
Oryza sativa 4336257   Os04g0492600
Saccharomyces cerevisiae YDR283C   Gcn2p
Schistosoma japonicum Sjp_0071960   ko:K08860 eukaryotic translation initiation factor 2-alpha kinase, putative
Schistosoma mansoni Smp_079390   protein kinase
Schmidtea mediterranea mk4.010831.00   Eukaryotic translation initiation factor 2-alpha kinase 4
Trichomonas vaginalis TVAG_074170   STE family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0088 0.4477 0.4477
0.0007 0.5 0.5
0.0016 0.5 0.5
0.0032 0.5 0.5
0.0032 0.5 0.5
0.0039 0.9485 0.9402
0.0012 0.5 0.5
0.0039 0.5 0.5
0.0059 1 1
0.0012 0.5 0.5
0.0059 1 1
0.0061 0.6883 0.6883
0.0064 0.3377 0.9531
0.0037 1 1
0.0069 0.3067 0.3067
0.0011 1 1
0.0081 0.5 0.5
0.0067 0.5 0.5
0.0092 1 1
0.0033 1 1
0.0027 1 1
0.0066 0.3101 0.9479
0.0004 0.5 0.5
0.0026 0.5 0.5
0.0098 0.3242 0.2282
0.0023 0.5 0.5
0.0033 0.5 0.5
0.0036 0.5 0.5
0.0007 0.5 0.5
0.0016 0.5 0.5
0.0063 1 1
0.0007 0.5 0.5
0.0062 0.6935 0.7231
0.0039 0.5 0.5
0.0081 1 1
0.0003 0.5 0.5
0.0091 1 1
0.0008 0.5 0.5
0.0063 0.7244 0
0.0093 0.8828 0
0.0018 0.5 0.5
0.0022 0.5 0.5
0.0056 1 1
0.0012 0.5 0.5
0.0029 0.5 0.5
0.0042 0.5 0.5
0.0059 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EmuJ_000527600 (Echinococcus multilocularis), eukaryotic translation initiation factor 2 alpha
Title for this comment
Comment