Detailed view for EmuJ_000055900

Basic information

TDR Targets ID: 960550
Echinococcus multilocularis, protein quaking
Source Database / ID:  GeneDB

pI: 7.9873 | Length (AA): 465 | MW (Da): 49756 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF16544   Homodimerisation region of STAR domain protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0006417   regulation of translation  
GO:0003727   single-stranded RNA binding  
GO:0003723   RNA binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 224 4jvy (A) 144 328 54.00 0 1 1.1178 -1.1
33 220 4jvh (A) 12 201 60.00 0 1 1.0842 -0.75
34 78 4dnn (A) 0 60 42.00 0.009 0.82 0.630774 -1.24
37 195 5elt (B) 4 155 41.00 0 1 0.743836 -0.17
254 299 4x8w (H) 1 305 50.00 0.35 0.07 0.249825 3.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130594)

Species Accession Gene Product
Arabidopsis thaliana AT4G26485   hypothetical protein
Arabidopsis thaliana AT4G26480   RNA-binding KH domain-containing protein
Arabidopsis thaliana AT5G56140   KH domain-containing protein
Arabidopsis thaliana AT4G26483   nicotianamine synthase
Arabidopsis thaliana AT2G38610   RNA-binding KH domain-containing protein
Arabidopsis thaliana AT1G09660   RNA-binding KH domain-containing protein
Arabidopsis thaliana AT3G08620   RNA-binding KH domain-containing protein
Brugia malayi Bm1_17630   hypothetical protein
Caenorhabditis elegans CELE_T21G5.5   Protein ASD-2, isoform C
Drosophila melanogaster Dmel_CG10293   held out wings
Echinococcus granulosus EgrG_000054370   protein quaking
Echinococcus granulosus EgrG_000055900   hypothetical protein
Echinococcus multilocularis EmuJ_000055900   protein quaking
Homo sapiens ENSG00000112531   QKI, KH domain containing, RNA binding
Loa Loa (eye worm) LOAG_03229   hypothetical protein
Mus musculus ENSMUSG00000062078   quaking
Oryza sativa 4324889   Os01g0886300
Oryza sativa 4342758   Os07g0227400
Oryza sativa 4334557   Os03g0815700
Oryza sativa 4338818   Os05g0419500
Oryza sativa 4330567   Os02g0722700
Schistosoma japonicum Sjp_0301670   Protein held out wings, putative
Schistosoma mansoni Smp_171860   hypothetical protein
Schmidtea mediterranea mk4.021079.02   Kh-domain rna binding protein-related
Schmidtea mediterranea mk4.000015.12   Protein quaking
Schmidtea mediterranea mk4.022736.00   Protein quaking
Schmidtea mediterranea mk4.006891.01   Protein quaking
Schmidtea mediterranea mk4.017898.00   Protein quaking

Essentiality

EmuJ_000055900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T21G5.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_T21G5.5 Caenorhabditis elegans larval arrest wormbase
CELE_T21G5.5 Caenorhabditis elegans larval lethal wormbase
CELE_T21G5.5 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000055900 (Echinococcus multilocularis), protein quaking
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