pI: 5.8215 |
Length (AA): 3565 |
MW (Da): 395540 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 12 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 485 | 4aqs (A) | 41 | 482 | 32.00 | 0 | 1 | 0.224603 | 1.18 |
69 | 346 | 3zyj (B) | 90 | 365 | 29.00 | 0 | 0.93 | 0.27038 | 0.58 |
80 | 405 | 2y38 (A) | 120 | 433 | 46.00 | 0 | 1 | 0.502845 | 0.46 |
1159 | 1196 | 4z81 (A) | 520 | 553 | 56.00 | 0.14 | 1 | 0.575059 | -0.27 |
1213 | 1328 | 6bwv (D) | 28 | 160 | 29.00 | 0.42 | 1 | 0.170939 | 0.59 |
1687 | 1736 | 1tle (A) | 3 | 57 | 38.00 | 0.0003 | 0.9 | 0.374425 | -0.03 |
1687 | 1827 | 1klo (A) | 11 | 161 | 43.00 | 0 | 1 | 0.373951 | 0.53 |
1687 | 1827 | 1klo (A) | 11 | 161 | 38.00 | 0 | 0.99 | 0.146851 | 0.74 |
2198 | 2370 | 4uos (A) | 9 | 169 | 23.00 | 0.38 | 0.64 | 0.313927 | -1.04 |
2412 | 2630 | 4tql (A) | 10 | 231 | 8.00 | 0.95 | 0.04 | 0.158431 | -0.46 |
3376 | 3564 | 3sh4 (A) | 5 | 194 | 8.00 | 0.0074 | 0.24 | 0.0790154 | -0.05 |
3382 | 3548 | 1pz7 (A) | 22 | 190 | 14.00 | 0.0013 | 0.18 | 0.134844 | -0.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126876)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_27925 | Laminin-like protein C54D1.5 precursor |
Brugia malayi | Bm1_24440 | laminin alpha chain |
Brugia malayi | Bm1_38590 | laminin-like protein K08C7.3 precursor |
Caenorhabditis elegans | CELE_K08C7.3 | Protein EPI-1, isoform C |
Caenorhabditis elegans | CELE_C54D1.5 | Protein LAM-2 |
Caenorhabditis elegans | CELE_T22A3.8 | Protein LAM-3 |
Drosophila melanogaster | Dmel_CG42677 | wing blister |
Drosophila melanogaster | Dmel_CG10236 | Laminin A |
Drosophila melanogaster | Dmel_CG3322 | Laminin B2 |
Echinococcus granulosus | EgrG_001132400 | laminin |
Echinococcus granulosus | EgrG_000458400 | Laminin subunit gamma |
Echinococcus granulosus | EgrG_000494300 | Pfam-B_16336 domain containing protein |
Echinococcus multilocularis | EmuJ_000494300 | conserved hypothetical protein |
Echinococcus multilocularis | EmuJ_000458400 | Laminin subunit gamma |
Echinococcus multilocularis | EmuJ_001132400 | laminin |
Homo sapiens | ENSG00000050555 | laminin, gamma 3 |
Homo sapiens | ENSG00000112769 | laminin, alpha 4 |
Homo sapiens | ENSG00000135862 | laminin, gamma 1 (formerly LAMB2) |
Homo sapiens | ENSG00000196569 | laminin, alpha 2 |
Homo sapiens | ENSG00000101680 | laminin, alpha 1 |
Homo sapiens | ENSG00000130702 | laminin, alpha 5 |
Homo sapiens | ENSG00000053747 | laminin, alpha 3 |
Homo sapiens | ENSG00000058085 | laminin, gamma 2 |
Loa Loa (eye worm) | LOAG_07978 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05302 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01359 | laminin alpha 1 chain |
Loa Loa (eye worm) | LOAG_02515 | abnormal epIthelia family member |
Loa Loa (eye worm) | LOAG_07250 | LAM-2 |
Mus musculus | ENSMUSG00000024421 | laminin, alpha 3 |
Mus musculus | ENSMUSG00000019899 | laminin, alpha 2 |
Mus musculus | ENSMUSG00000032796 | laminin, alpha 1 |
Mus musculus | ENSMUSG00000019846 | laminin, alpha 4 |
Mus musculus | ENSMUSG00000015647 | laminin, alpha 5 |
Mus musculus | ENSMUSG00000026479 | laminin, gamma 2 |
Mus musculus | ENSMUSG00000026840 | laminin gamma 3 |
Mus musculus | ENSMUSG00000026478 | laminin, gamma 1 |
Schistosoma japonicum | Sjp_0044160 | ko:K05635 laminin, gamma 1, putative |
Schistosoma japonicum | Sjp_0008530 | ko:K05637 laminin, alpha 1, putative |
Schistosoma japonicum | Sjp_0008540 | IPR001791,Laminin G;IPR008985,Concanavalin A-like lectin/glucanase,domain-containing |
Schistosoma japonicum | Sjp_0116780 | IPR008211,Laminin, N-terminal,domain-containing |
Schistosoma mansoni | Smp_143680 | laminin |
Schistosoma mansoni | Smp_163810 | laminin gamma-1 chain |
Schmidtea mediterranea | mk4.012094.00 | |
Schmidtea mediterranea | mk4.042317.00 | |
Schmidtea mediterranea | mk4.002835.01 | |
Schmidtea mediterranea | mk4.008300.01 | |
Schmidtea mediterranea | mk4.015198.01 | Usherin |
Schmidtea mediterranea | mk4.007465.00 | |
Schmidtea mediterranea | mk4.015198.00 | |
Schmidtea mediterranea | mk4.017357.00 | |
Schmidtea mediterranea | mk4.000676.10 | Laminin alpha chain |
Schmidtea mediterranea | mk4.000676.09 | Laminin-like protein lam-2 |
Schmidtea mediterranea | mk4.001093.02 | |
Schmidtea mediterranea | mk4.000676.12 | |
Schmidtea mediterranea | mk4.003468.03 | |
Schmidtea mediterranea | mk4.008300.00 | Laminin-like protein lam-2 |
Schmidtea mediterranea | mk4.001388.07 | |
Schmidtea mediterranea | mk4.000676.11 | |
Schmidtea mediterranea | mk4.002173.07 | |
Schmidtea mediterranea | mk4.000676.08 | |
Schmidtea mediterranea | mk4.015198.02 | |
Schmidtea mediterranea | mk4.008300.02 | Usherin |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_K08C7.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K08C7.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K08C7.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_K08C7.3 | Caenorhabditis elegans | sterile | wormbase |
CELE_T22A3.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T22A3.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C54D1.5 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_C54D1.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C54D1.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C54D1.5 | Caenorhabditis elegans | sterile | wormbase |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.