Detailed view for EmuJ_001193500

Basic information

TDR Targets ID: 961192
Echinococcus multilocularis, thioredoxin domain containing protein 17
Source Database / ID:  GeneDB

pI: 8.1189 | Length (AA): 118 | MW (Da): 13627 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06110   Eukaryotic protein of unknown function (DUF953)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 118 1wou (A) 7 122 34.00 0 1 1.6537 -2.31
39 91 2rdu (A) 136 188 42.00 0.2 0.19 0.743853 0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130033)

Species Accession Gene Product
Arabidopsis thaliana AT5G15050   core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein
Arabidopsis thaliana AT5G39990   core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein
Caenorhabditis elegans CELE_Y50D4C.4   Protein SQV-6
Drosophila melanogaster Dmel_CG32300   peptide O-xylosyltransferase
Echinococcus granulosus EgrG_000670200   xylosyltransferase
Echinococcus granulosus EgrG_001193500   thioredoxin domain containing protein 17
Echinococcus multilocularis EmuJ_000670200   xylosyltransferase
Echinococcus multilocularis EmuJ_001193500   thioredoxin domain containing protein 17
Homo sapiens ENSG00000015532   xylosyltransferase II
Homo sapiens ENSG00000103489   xylosyltransferase I
Loa Loa (eye worm) LOAG_09921   hypothetical protein
Loa Loa (eye worm) LOAG_15561   hypothetical protein
Mus musculus ENSMUSG00000020868   xylosyltransferase II
Mus musculus ENSMUSG00000030657   xylosyltransferase 1
Oryza sativa 4333784   Os03g0692000
Oryza sativa 4352919   Os12g0639700
Oryza sativa 4335418   Os04g0301700
Schistosoma japonicum Sjp_0301860   ko:K00771 protein xylosyltransferase [EC2.4.2.26], putative
Schistosoma japonicum Sjp_0001660   Thioredoxin domain-containing protein 17, putative
Schistosoma mansoni Smp_128310.2   xylosyltransferase
Schistosoma mansoni Smp_128310.1   xylosyltransferase
Schmidtea mediterranea mk4.005945.04   Xylosyltransferase sqv-6
Schmidtea mediterranea mk4.009512.02   Xylosyltransferase sqv-6

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Streptomyces caespitosus Type-2 restriction enzyme ScaI Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001193500 (Echinococcus multilocularis), thioredoxin domain containing protein 17
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