Detailed view for EmuJ_000929600

Basic information

TDR Targets ID: 961340
Echinococcus multilocularis, beta arrestin 1
Source Database / ID:  GeneDB

pI: 10.0472 | Length (AA): 640 | MW (Da): 71169 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02752   Arrestin (or S-antigen), C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
104 164 1xu6 (A) 361 421 11.00 0 0.01 0.312512 -1.15
146 525 3p2d (A) 6 385 19.00 0 0.8 0.66205 0.71
250 470 1suj (A) 90 303 25.00 0 0.97 0.429513 1.44
319 403 3h0x (A) 499 571 36.00 0.54 0.2 0.232112 1.12
479 585 4r4g (A) 192 298 19.00 0 0.01 0.468388 -1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131375)

Species Accession Gene Product
Brugia malayi Bm1_33905   Probable beta-arrestin
Caenorhabditis elegans CELE_F53H8.2   Protein ARR-1
Drosophila melanogaster Dmel_CG1487   kurtz
Echinococcus granulosus EgrG_000929600   beta arrestin 1
Echinococcus granulosus EgrG_000855900   beta arrestin 1
Echinococcus granulosus EgrG_000201100   beta arrestin 1
Echinococcus multilocularis EmuJ_000929600   beta arrestin 1
Echinococcus multilocularis EmuJ_000855900   beta arrestin 1
Echinococcus multilocularis EmuJ_000201100   beta arrestin 1
Homo sapiens ENSG00000141480   arrestin, beta 2
Homo sapiens ENSG00000137486   arrestin, beta 1
Loa Loa (eye worm) LOAG_00353   hypothetical protein
Mus musculus ENSMUSG00000060216   arrestin, beta 2
Mus musculus ENSMUSG00000018909   arrestin, beta 1
Schistosoma japonicum Sjp_0047270   Beta-arrestin-1, putative
Schistosoma japonicum Sjp_0047250   Arrestin red cell isoform 2, putative
Schistosoma japonicum Sjp_0301390   ko:K04439 arrestin, putative
Schistosoma mansoni Smp_122900   beta-arrestin 1
Schistosoma mansoni Smp_126080   beta-arrestin 1
Schmidtea mediterranea mk4.001548.06   Probable beta-arrestin
Schmidtea mediterranea mk4.002491.01   Probable beta-arrestin
Schmidtea mediterranea mk4.002443.03   Putative beta-arrestin 1
Schmidtea mediterranea mk4.028324.00   Probable beta-arrestin
Schmidtea mediterranea mk4.017531.01   Probable beta-arrestin
Schmidtea mediterranea mk4.017531.00   Probable beta-arrestin
Schmidtea mediterranea mk4.019360.00  
Schmidtea mediterranea mk4.008606.02   Probable beta-arrestin
Schmidtea mediterranea mk4.021470.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens arrestin, beta 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000929600 (Echinococcus multilocularis), beta arrestin 1
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