Detailed view for EmuJ_000138600

Basic information

TDR Targets ID: 961720
Echinococcus multilocularis, glutamate receptor interacting protein 1
Source Database / ID:  GeneDB

pI: 8.096 | Length (AA): 1342 | MW (Da): 147368 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF05676   NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008137   NADH dehydrogenase (ubiquinone) activity  
GO:0005739   mitochondrion  
GO:0005515   protein binding  
GO:0003954   NADH dehydrogenase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 15 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 93 3dj1 (A) 9 92 18.00 0.23 0.04 0.0611996 0.58
32 77 3rl7 (E) 220 275 17.00 0.84 0.22 0.220177 -0.48
55 115 2jil (A) 183 240 40.00 0.0016 0.67 0.454955 -0.05
135 171 1x5r (A) 57 93 54.00 0.0031 0.67 0.606071 0.16
206 418 1p1d (A) 22 213 42.00 0 1 0.509218 0.37
328 421 2vrf (A) 0 202 32.00 0 1 0.554845 -1.17
333 419 2fne (A) 1959 2046 28.00 0 1 0.555629 -1.41
543 620 2jre (A) 11 85 37.00 0.0023 0.97 0.324622 0.38
544 604 1wh1 (A) 19 80 36.00 0.051 0.7 0.387955 0.65
545 604 5vwi (A) 12 75 45.00 0.55 0.67 0.350209 0.49
1043 1147 2mqa (A) 22 121 11.00 0 0.01 0.148041 -0.28
1147 1250 1um7 (A) 5 108 19.00 0.48 0.07 0.258396 -0.18
1166 1219 2byg (A) 199 258 26.00 0.26 0.26 0.140138 0.42
1171 1242 1uf1 (A) 29 108 43.00 0.3 0.82 0.239151 0.84
1220 1315 5bmo (A) 5 95 34.00 0.065 0.11 0.239035 1.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131508)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG14447   Glutamate receptor binding protein
Echinococcus granulosus EgrG_000145900   glutamate receptor interacting protein 1
Echinococcus multilocularis EmuJ_000145900   glutamate receptor interacting protein 1
Echinococcus multilocularis EmuJ_000138600   glutamate receptor interacting protein 1
Homo sapiens ENSG00000155974   glutamate receptor interacting protein 1
Homo sapiens ENSG00000144596   glutamate receptor interacting protein 2
Loa Loa (eye worm) LOAG_12616   hypothetical protein
Loa Loa (eye worm) LOAG_13539   hypothetical protein
Loa Loa (eye worm) LOAG_13259   hypothetical protein
Loa Loa (eye worm) LOAG_15713   hypothetical protein
Mus musculus ENSMUSG00000034813   glutamate receptor interacting protein 1
Mus musculus ENSMUSG00000030098   glutamate receptor interacting protein 2
Schistosoma japonicum Sjp_0054030   IPR001478,PDZ/DHR/GLGF,domain-containing
Schistosoma japonicum Sjp_0073680   Glutamate receptor-interacting protein 1, putative
Schistosoma japonicum Sjp_0310180   Glutamate receptor-interacting protein 2, putative
Schistosoma japonicum Sjp_0212440   IPR001478,PDZ/DHR/GLGF,domain-containing
Schistosoma mansoni Smp_141070   hypothetical protein
Schistosoma mansoni Smp_141060   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Glutamate receptor-interacting protein 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000138600 (Echinococcus multilocularis), glutamate receptor interacting protein 1
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