Detailed view for EmuJ_000594300

Basic information

TDR Targets ID: 962517
Echinococcus multilocularis, SH3 and multiple ankyrin repeat domains protein
Source Database / ID:  GeneDB

pI: 9.2022 | Length (AA): 952 | MW (Da): 102173 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF12796   Ankyrin repeats (3 copies)
PF13637   Ankyrin repeats (many copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

Glutamatergic synapse (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
31 298 5g4x (A) 81 347 48.00 0 1 0.922613 -0.75
67 168 2xzd (G) 16 115 41.00 0.00000017 1 0.671243 -1.28
76 431 4rlv (A) 2244 2598 29.00 0 1 0.48205 0.48
135 258 1n0q (A) 4 92 47.00 0.000000001 0.69 0.222352 0.43
135 178 2vge (A) 662 706 41.00 0.87 0.94 0.588318 -0.72
353 441 5cbn (A) 43 133 12.00 0.00000037 0.04 0.324587 -1.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129937)

Species Accession Gene Product
Brugia malayi Bm1_44025   Shank2E
Caenorhabditis elegans CELE_C33B4.3   Protein SHN-1, isoform A
Drosophila melanogaster Dmel_CG30483   CG30483 gene product from transcript CG30483-RD
Echinococcus granulosus EgrG_000594300   SH3 and multiple ankyrin repeat domains protein
Echinococcus granulosus EgrG_001127100   SH3 and multiple ankyrin repeat domains protein
Echinococcus multilocularis EmuJ_001127100   SH3 and multiple ankyrin repeat domains protein
Echinococcus multilocularis EmuJ_000594300   SH3 and multiple ankyrin repeat domains protein
Homo sapiens 85358   SH3 and multiple ankyrin repeat domains 3
Homo sapiens ENSG00000161681   SH3 and multiple ankyrin repeat domains 1
Homo sapiens ENSG00000162105   SH3 and multiple ankyrin repeat domains 2
Mus musculus ENSMUSG00000038738   SH3/ankyrin domain gene 1
Mus musculus ENSMUSG00000022623   SH3/ankyrin domain gene 3
Mus musculus ENSMUSG00000037541   SH3/ankyrin domain gene 2
Onchocerca volvulus OVOC10691  
Schistosoma japonicum Sjp_0127420   SH3 and multiple ankyrin repeat domains protein 3, putative
Schistosoma japonicum Sjp_0111650   IPR001478,PDZ/DHR/GLGF,domain-containing
Schistosoma japonicum Sjp_0116230   SH3 and multiple ankyrin repeat domains protein 1, putative
Schistosoma mansoni Smp_141910   sh3 and multiple ankyrin repeat domains protein 12 (shank12)
Schmidtea mediterranea mk4.027051.00   Putative sh3 and multiple ankyrin repeat domains protein 1,2
Schmidtea mediterranea mk4.014663.00   Putative sh3 and multiple ankyrin repeat domains protein 1,2
Schmidtea mediterranea mk4.016249.00  
Schmidtea mediterranea mk4.001867.00   Putative sh3 and multiple ankyrin repeat domains protein 1,2
Schmidtea mediterranea mk4.002287.00  

Essentiality

EmuJ_000594300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C33B4.3 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000594300 (Echinococcus multilocularis), SH3 and multiple ankyrin repeat domains protein
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