Detailed view for EmuJ_000773900

Basic information

TDR Targets ID: 962638
Echinococcus multilocularis, mitochondrial import inner membrane translocase
Source Database / ID:  GeneDB

pI: 7.8408 | Length (AA): 214 | MW (Da): 22936 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02466   Tim17/Tim22/Tim23/Pmp24 family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 65 2dmc (A) 36 71 50.00 0.091 0.36 0.388643 2.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128586)

Species Accession Gene Product
Arabidopsis thaliana AT3G10110   mitochondrial import inner membrane translocase subunit TIM22-1
Arabidopsis thaliana AT1G18320   mitochondrial import inner membrane translocase subunit TIM22-4
Babesia bovis BBOV_IV002410   mitochondrial import inner membrane translocase subunit Tim17, putative
Brugia malayi Bm1_42185   Mitochondrial import inner membrane translocase subunit Tim17 family protein
Candida albicans CaO19.1352   Mitochondrial inner membrane protein.
Candida albicans CaO19.8932   Mitochondrial inner membrane protein.
Candida albicans CaO19.2658   mitochondrial inner membrane protein.
Caenorhabditis elegans CELE_C47G2.3   Protein C47G2.3
Dictyostelium discoideum DDB_G0283865   hypothetical protein
Drosophila melanogaster Dmel_CG31229   CG31229 gene product from transcript CG31229-RA
Echinococcus granulosus EgrG_000773900   mitochondrial import inner membrane translocase
Echinococcus multilocularis EmuJ_000773900   mitochondrial import inner membrane translocase
Homo sapiens 29928   translocase of inner mitochondrial membrane 22 homolog (yeast)
Leishmania braziliensis LbrM.09.1180   mitochondrial import inner membrane translocase subunit tim17, putative,inner membrane preprotein translocase Tim17, putative
Leishmania donovani LdBPK_091190.1   mitochondrial import inner membrane translocase subunit TIM17, putative
Leishmania infantum LinJ.09.1190   mitochondrial import inner membrane translocase subunit tim17, putative,inner membrane preprotein translocase Tim17, putative
Leishmania major LmjF.09.1130   mitochondrial import inner membrane translocase subunit tim17, putative,inner membrane preprotein translocase Tim17, putative
Leishmania mexicana LmxM.09.1130   mitochondrial import inner membrane translocase subunit tim17, putative,inner membrane preprotein translocase Tim17, putative
Mus musculus ENSMUSG00000020843   translocase of inner mitochondrial membrane 22
Neospora caninum NCLIV_047100   hypothetical protein
Oryza sativa 4332537   Os03g0296300
Plasmodium berghei PBANKA_1126100   mitochondrial import inner membrane translocase subunit TIM22, putative
Plasmodium falciparum PF3D7_0627400   mitochondrial import inner membrane translocase subunit TIM22, putative
Plasmodium knowlesi PKNH_1122400   mitochondrial import inner membrane translocase subunit TIM22, putative
Plasmodium vivax PVX_114475   mitochondrial import inner membrane translocase subunit TIM22, putative
Plasmodium yoelii PY04639   mitochondrial import inner membrane translocase subunit tim22 homolog
Saccharomyces cerevisiae YDL217C   Tim22p
Schistosoma japonicum Sjp_0020600   Mitochondrial import inner membrane translocase subunit Tim22, putative
Schistosoma mansoni Smp_038630   mitochondrial import inner membrane translocase subunit tim22
Schmidtea mediterranea mk4.000142.05   Putative mitochondrial import inner membrane translocase subunit tim22
Trypanosoma brucei gambiense Tbg972.11.14830   inner membrane preprotein translocase Tim17, putative
Trypanosoma brucei Tb927.11.13290   mitochondrial import inner membrane translocase subunit tim17
Trypanosoma congolense TcIL3000.11.13660   mitochondrial import inner membrane translocase subunit tim17
Trypanosoma cruzi TcCLB.510359.260   mitochondrial import inner membrane translocase subunit TIM17, putative
Trypanosoma cruzi TcCLB.506755.250   mitochondrial import inner membrane translocase subunit TIM17, putative
Toxoplasma gondii TGME49_225710   mitochondrial inner membrane translocase subunit TIM17, putative
Theileria parva TP03_0412   hypothetical protein

Essentiality

EmuJ_000773900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.4870 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.4870 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.4870 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.4870 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C47G2.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_C47G2.3 Caenorhabditis elegans sterile wormbase
YDL217C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1126100 Plasmodium berghei Essential plasmo
TGME49_225710 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000773900 (Echinococcus multilocularis), mitochondrial import inner membrane translocase
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