pI: 5.3887 |
Length (AA): 261 |
MW (Da): 30045 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 248 | 4odi (A) | 16 | 257 | 49.00 | 0 | 1 | 1.6282 | -1.26 |
8 | 254 | 1e58 (A) | 1 | 247 | 44.00 | 0 | 1 | 1.57836 | -1.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127491)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G78050 | phosphoglycerate/bisphosphoglycerate mutase |
Arabidopsis thaliana | AT1G22170 | phosphoglycerate mutase family protein |
Babesia bovis | BBOV_III007860 | phosphoglycerate mutase 1 family protein |
Candida albicans | CaO19.8522 | phosphoglycerate mutase similar to S. cerevisiae GPM1 (YKL152C) |
Candida albicans | CaO19.903 | phosphoglycerate mutase similar to S. cerevisiae GPM1 (YKL152C) |
Cryptosporidium hominis | Chro.70471 | phosphoglycerate mutase |
Cryptosporidium parvum | cgd7_4270 | glycolytic phosphoglycerate mutase |
Chlamydia trachomatis | CT_722 | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase |
Dictyostelium discoideum | DDB_G0285311 | phosphoglycerate mutase |
Drosophila melanogaster | Dmel_CG1721 | Phosphoglyceromutase |
Drosophila melanogaster | Dmel_CG17645 | CG17645 gene product from transcript CG17645-RA |
Escherichia coli | b0755 | phosphoglyceromutase 1 |
Echinococcus granulosus | EgrG_000907900 | phosphoglycerate mutase |
Echinococcus granulosus | EgrG_000799500 | phosphoglycerate mutase |
Echinococcus granulosus | EgrG_000907800 | phosphoglycerate mutase |
Echinococcus multilocularis | EmuJ_000907800 | phosphoglycerate mutase |
Echinococcus multilocularis | EmuJ_000907900 | phosphoglycerate mutase |
Echinococcus multilocularis | EmuJ_000799500 | phosphoglycerate mutase |
Homo sapiens | ENSG00000164708 | phosphoglycerate mutase 2 (muscle) |
Homo sapiens | ENSG00000171314 | phosphoglycerate mutase 1 (brain) |
Homo sapiens | ENSG00000172331 | 2,3-bisphosphoglycerate mutase |
Mycobacterium leprae | ML2441c | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) |
Mus musculus | ENSMUSG00000011752 | phosphoglycerate mutase 1 |
Mus musculus | ENSMUSG00000020475 | phosphoglycerate mutase 2 |
Mus musculus | ENSMUSG00000038871 | 2,3-bisphosphoglycerate mutase |
Mycobacterium tuberculosis | Rv0489 | Probable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) |
Mycobacterium ulcerans | MUL_4558 | phosphoglyceromutase |
Neospora caninum | NCLIV_006170 | Phosphoglycerate mutase, related |
Oryza sativa | 4330747 | Os02g0751800 |
Plasmodium berghei | PBANKA_0928100 | phosphoglycerate mutase, putative |
Plasmodium falciparum | PF3D7_1120100 | phosphoglycerate mutase, putative |
Plasmodium knowlesi | PKNH_0917800 | phosphoglycerate mutase, putative |
Plasmodium vivax | PVX_091640 | phosphoglycerate mutase, putative |
Saccharomyces cerevisiae | YKL152C | phosphoglycerate mutase GPM1 |
Schistosoma japonicum | Sjp_0304750 | ko:K01834 phosphoglycerate mutase [EC5.4.2.1], putative |
Schistosoma mansoni | Smp_096760 | phosphoglycerate mutase |
Schmidtea mediterranea | mk4.066543.00 | Bisphosphoglycerate mutase |
Schmidtea mediterranea | mk4.000988.02 | Bisphosphoglycerate mutase |
Schmidtea mediterranea | mk4.038083.04 | Bisphosphoglycerate mutase |
Toxoplasma gondii | TGME49_297060 | phosphoglycerate mutase PGMII |
Treponema pallidum | TP0168 | phosphoglyceromutase |
Theileria parva | TP04_0690 | phosphoglycerate mutase I, putative |
Trichomonas vaginalis | TVAG_209020 | phosphoglycerate mutase, putative |
Trichomonas vaginalis | TVAG_212740 | phosphoglycerate mutase, putative |
Trichomonas vaginalis | TVAG_113710 | phosphoglycerate mutase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b0755 | Escherichia coli | non-essential | goodall |
YKL152C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0928100 | Plasmodium berghei | Essential | plasmo |
TGME49_297060 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | phosphoglycerate mutase 1 (brain) | Compounds | References |