Detailed view for EmuJ_000066700

Basic information

TDR Targets ID: 963987
Echinococcus multilocularis, pyridoxal dependent decarboxylase
Source Database / ID:  GeneDB

pI: 6.0447 | Length (AA): 821 | MW (Da): 91332 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00282   Pyridoxal-dependent decarboxylase conserved domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030170   pyridoxal phosphate binding  
GO:0016831   carboxy-lyase activity  
GO:0003824   catalytic activity  
GO:0019752   carboxylic acid metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
74 431 4e1o (A) 131 475 16.00 0 0.97 0.579454 0.13
125 235 4e1o (A) 175 282 31.00 0.019 0.99 0.467801 -0.44
129 230 4rit (B) 175 272 32.00 0.00061 0.97 0.588839 -0.98
182 276 2okk (A) 316 410 33.00 0.00082 0.68 0.422313 0.71
626 751 4pjq (A) 91 221 31.00 0.46 0.24 0.357071 -0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132557)

Species Accession Gene Product
Brugia malayi Bm1_37205   hypothetical protein
Brugia malayi Bm1_37200   GH01474p
Caenorhabditis elegans CELE_C14H10.3   Protein C14H10.3, isoform B
Drosophila melanogaster Dmel_CG1486   CG1486 gene product from transcript CG1486-RA
Echinococcus granulosus EgrG_000066700   pyridoxal dependent decarboxylase
Echinococcus multilocularis EmuJ_000066700   pyridoxal dependent decarboxylase
Homo sapiens ENSG00000179889   pyridoxal-dependent decarboxylase domain containing 1
Homo sapiens 102724985   pyridoxal-dependent decarboxylase domain-containing protein 1-like
Loa Loa (eye worm) LOAG_00572   hypothetical protein
Mus musculus ENSMUSG00000022680   pyridoxal-dependent decarboxylase domain containing 1
Onchocerca volvulus OVOC4458  
Schmidtea mediterranea mk4.000908.09  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000066700 (Echinococcus multilocularis), pyridoxal dependent decarboxylase
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