pI: 8.3759 |
Length (AA): 179 |
MW (Da): 20648 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 157 | 6c9m (B) | 1 | 157 | 78.00 | 0 | 1 | 1.85489 | -1.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126956)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G13780 | peptide alpha-N-acetyltransferase |
Babesia bovis | BBOV_II004010 | N-acetyltransferase, putative |
Brugia malayi | Bm1_15190 | N-terminal acetyltransferase complex ARD1 subunit homolog |
Brugia malayi | Bm1_03265 | N-terminal acetyltransferase complex ARD1 subunit homolog |
Candida albicans | CaO19.7617 | potential peptide N-acetyl tranferase (GNAT family) similar to S. cerevisiae ARD1 (YHR013C) subunit of the Ard1p/Nat1p major pep |
Caenorhabditis elegans | CELE_K07H8.3 | Protein K07H8.3 |
Cryptosporidium hominis | Chro.50064 | N-acetyltransferase |
Cryptosporidium parvum | cgd5_3090 | N-acetyltransferase subunit ARD1 |
Dictyostelium discoideum | DDB_G0275449 | N-acetyltransferase complex subunit |
Drosophila melanogaster | Dmel_CG11989 | variable nurse cells |
Escherichia coli | b4373 | ribosomal-protein-S18-alanine N-acetyltransferase |
Echinococcus granulosus | EgrG_000792500 | N alpha acetyltransferase 11 |
Entamoeba histolytica | EHI_005070 | acetyltransferase, GNAT family |
Entamoeba histolytica | EHI_186730 | acetyltransferase, GNAT family |
Echinococcus multilocularis | EmuJ_000792500 | N alpha acetyltransferase 11 |
Giardia lamblia | GL50803_8707 | N-terminal acetyltransferase complex ARD1 subunit, putative |
Homo sapiens | 8260 | N(alpha)-acetyltransferase 10, NatA catalytic subunit |
Homo sapiens | 84779 | N(alpha)-acetyltransferase 11, NatA catalytic subunit |
Leishmania braziliensis | LbrM.29.2720 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_130260.1 | N-acetyltransferase subunit ARD1, putative |
Leishmania infantum | LinJ.13.0260 | N-acetyltransferase subunit ARD1, putative |
Leishmania major | LmjF.13.0260 | N-acetyltransferase subunit ARD1, putative |
Leishmania mexicana | LmxM.13.0260 | N-acetyltransferase subunit ARD1, putative |
Loa Loa (eye worm) | LOAG_10487 | n-terminal acetyltransferase complex ard1 subunit |
Mus musculus | ENSMUSG00000031388 | N(alpha)-acetyltransferase 10, NatA catalytic subunit |
Mus musculus | ENSMUSG00000046000 | N(alpha)-acetyltransferase 11, NatA catalytic subunit |
Mycobacterium tuberculosis | Rv3420c | Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18) |
Mycobacterium ulcerans | MUL_0883 | ribosomal-protein-alanine acetyltransferase, RimI |
Neospora caninum | NCLIV_060850 | N-terminal acetyltransferase complex subunit ARD1, putative |
Oryza sativa | 4337136 | Os04g0635800 |
Onchocerca volvulus | OVOC6155 |
|
Plasmodium berghei | PBANKA_1201700 | N-terminal acetyltransferase A complex catalytic subunit ARD1, putative |
Plasmodium falciparum | PF3D7_1003300 | N-terminal acetyltransferase A complex catalytic subunit ARD1, putative |
Plasmodium knowlesi | PKNH_0802100 | N-terminal acetyltransferase A complex catalytic subunit ARD1, putative |
Plasmodium vivax | PVX_094365 | N-acetyltransferase, putative |
Plasmodium yoelii | PY00941 | hypothetical protein |
Saccharomyces cerevisiae | YHR013C | Ard1p |
Schistosoma japonicum | Sjp_0031810 | ko:K00680 N-acetyltransferase ARD1 homolog [EC:2.3.1.-], putative |
Schistosoma mansoni | Smp_050590 | n-terminal acetyltransferase complex ard1 subunit |
Schmidtea mediterranea | mk4.000152.10 | Putative n-terminal acetyltransferase complex ard1 subunit |
Trypanosoma brucei gambiense | Tbg972.11.5170 | N-acetyltransferase subunit ARD1, putative |
Trypanosoma brucei | Tb927.11.4530 | N-acetyltransferase subunit ARD1 |
Trypanosoma congolense | TcIL3000.11.4620 | N-acetyltransferase subunit ARD1, putative |
Trypanosoma cruzi | TcCLB.506227.230 | N-acetyltransferase complex ARD1 subunit, putative |
Toxoplasma gondii | TGME49_219760 | N-acetyltransferase family protein |
Theileria parva | TP04_0161 | N-acetyltransferase, putative |
Trichomonas vaginalis | TVAG_099870 | N-acetyltransferase, putative |
Trichomonas vaginalis | TVAG_497420 | ribosomal-protein-alanine acetyltransferase, putative |
Trichomonas vaginalis | TVAG_363980 | N-acetyltransferase, putative |
Trichomonas vaginalis | TVAG_159840 | ribosomal-protein-alanine acetyltransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.2110 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.2110 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.2110 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.2110 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b4373 | Escherichia coli | non-essential | goodall |
CELE_K07H8.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K07H8.3 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_219760 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.