pI: 10.7819 |
Length (AA): 145 |
MW (Da): 16296 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 143 | 4kzy (T) | 4 | 144 | 46.00 | 0 | 1 | 1.60012 | -0.83 |
5 | 143 | 2v7f (A) | 3 | 142 | 37.00 | 0 | 1 | 1.46922 | -1.29 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127080)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G02080 | 40S ribosomal protein S19-1 |
Arabidopsis thaliana | AT5G61170 | 40S ribosomal protein S19-3 |
Arabidopsis thaliana | AT5G15520 | 40S ribosomal protein S19-2 |
Babesia bovis | BBOV_III001110 | 40S ribosomal protein S19, putative |
Brugia malayi | Bm1_18840 | 40S ribosomal protein S19S |
Brugia malayi | Bm1_57295 | 40S ribosomal protein S19S |
Caenorhabditis elegans | CELE_T05F1.3 | Protein RPS-19 |
Cryptosporidium hominis | Chro.10106 | hypothetical protein |
Cryptosporidium parvum | cgd1_850 | 40S ribosomal protein S19 |
Dictyostelium discoideum | DDB_G0279207 | 40S ribosomal protein S19 |
Drosophila melanogaster | Dmel_CG4464 | Ribosomal protein S19a |
Drosophila melanogaster | Dmel_CG5338 | Ribosomal protein S19b |
Echinococcus granulosus | EgrG_000480600 | ribosomal protein S19e |
Entamoeba histolytica | EHI_198740 | 40S ribosomal protein S19, putative |
Entamoeba histolytica | EHI_146570 | 40S ribosomal protein S19, putative |
Echinococcus multilocularis | EmuJ_000480600 | ribosomal protein S19e |
Homo sapiens | 6223 | ribosomal protein S19 |
Leishmania braziliensis | LbrM.20.2340 | 40S ribosomal protein S19 protein, putative |
Leishmania braziliensis | LbrM.03.0920 | 40S ribosomal protein S19 protein |
Leishmania donovani | LdBPK_342620.1 | 40S ribosomal protein S19 protein, putative |
Leishmania infantum | LinJ.34.2620 | 40S ribosomal protein S19 protein, putative |
Leishmania infantum | LinJ.29.2970 | 40S ribosomal protein S19-like protein |
Leishmania major | LmjF.34.2780 | 40S ribosomal protein S19 protein, putative |
Leishmania major | LmjF.29.2860 | 40S ribosomal protein S19-like protein |
Leishmania mexicana | LmxM.08_29.2860 | 40S ribosomal protein S19-like protein |
Leishmania mexicana | LmxM.33.2780 | 40S ribosomal protein S19 protein, putative |
Loa Loa (eye worm) | LOAG_01581 | 40S ribosomal protein S19S |
Loa Loa (eye worm) | LOAG_04829 | 40S ribosomal protein S19S |
Mus musculus | ENSMUSG00000040952 | ribosomal protein S19 |
Neospora caninum | NCLIV_049100 | Ribosomal protein S19e, related |
Oryza sativa | 4333150 | Os03g0424800 |
Oryza sativa | 4333148 | Os03g0424500 |
Onchocerca volvulus | OVOC1707 | 40S ribosomal protein S19 homolog |
Onchocerca volvulus | OVOC776 | 40S ribosomal protein S19 homolog |
Plasmodium berghei | PBANKA_0522800 | 40S ribosomal protein S19, putative |
Plasmodium falciparum | PF3D7_0422400 | 40S ribosomal protein S19 |
Plasmodium knowlesi | PKNH_0514300 | 40S ribosomal protein S19, putative |
Plasmodium vivax | PVX_090160 | 40S ribosomal protein S19, putative |
Plasmodium yoelii | PY04062 | Ribosomal protein S19e, putative |
Saccharomyces cerevisiae | YNL302C | ribosomal 40S subunit protein S19B |
Saccharomyces cerevisiae | YOL121C | ribosomal 40S subunit protein S19A |
Schistosoma japonicum | Sjp_0034480 | ko:K02966 small subunit ribosomal protein S19e, putative |
Schistosoma mansoni | Smp_174950 | 40S ribosomal protein S19 |
Schmidtea mediterranea | mk4.001523.14 | 40S ribosomal protein S19 |
Schmidtea mediterranea | mk4.024113.00 | 40S ribosomal protein S19 |
Schmidtea mediterranea | mk4.017924.00 | 40S ribosomal protein S19 |
Schmidtea mediterranea | mk4.010902.02 | 40S ribosomal protein S19 |
Schmidtea mediterranea | mk4.010092.01 | 40S ribosomal protein S19 |
Trypanosoma brucei gambiense | Tbg972.4.1770 | ribosomal protein S19, putative |
Trypanosoma brucei | Tb927.4.1860 | ribosomal protein S19, putative |
Trypanosoma congolense | TcIL3000_4_1520 | ribosomal protein S19, putative |
Trypanosoma cruzi | TcCLB.504013.100 | ribosomal protein S19, putative |
Trypanosoma cruzi | TcCLB.510879.20 | ribosomal protein S19, putative |
Toxoplasma gondii | TGME49_212290 | ribosomal protein RPS19 |
Theileria parva | TP03_0716 | 40S ribosomal protein S19, putative |
Trichomonas vaginalis | TVAG_352580 | 40S ribosomal protein S19, putative |
Trichomonas vaginalis | TVAG_199240 | 40S ribosomal protein S19, putative |
Trichomonas vaginalis | TVAG_352560 | 40S ribosomal protein S19, putative |
Trichomonas vaginalis | TVAG_207570 | 40S ribosomal protein S19, putative |
Trichomonas vaginalis | TVAG_352520 | 40S ribosomal protein S19, putative |
Trichomonas vaginalis | TVAG_352600 | 40S ribosomal protein S19, putative |
Trichomonas vaginalis | TVAG_353280 | 40S ribosomal protein S19, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.1860 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.1860 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.1860 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.1860 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T05F1.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T05F1.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T05F1.3 | Caenorhabditis elegans | sterile | wormbase |
TGME49_212290 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.