pI: 5.0985 |
Length (AA): 398 |
MW (Da): 44446 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 45 | 4j8c (A) | 1 | 44 | 36.00 | 0.00022 | 1 | 0.657453 | -0.94 |
74 | 240 | 4j8f (A) | 384 | 550 | 51.00 | 0 | 1 | 1.1005 | -0.78 |
107 | 169 | 4cgu (A) | 1 | 63 | 22.00 | 0.84 | 0.87 | 0.573591 | -1.18 |
133 | 259 | 1kt1 (A) | 306 | 419 | 22.00 | 0 | 0.5 | 0.428595 | 0.21 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129249)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G22670 | HSP70-interacting protein 1 |
Arabidopsis thaliana | AT3G17880 | TPR repeat-containing thioredoxin TDX |
Brugia malayi | Bm1_46100 | TPR Domain containing protein |
Brugia malayi | Bm1_46110 | hypothetical protein |
Caenorhabditis elegans | CELE_T12D8.8 | Protein HIP-1 |
Drosophila melanogaster | Dmel_CG2947 | Hsc/Hsp70-interacting protein related |
Drosophila melanogaster | Dmel_CG32789 | Hsc/Hsp70-interacting protein |
Echinococcus granulosus | EgrG_000887500 | mitochondrial import receptor subunit tom34 |
Entamoeba histolytica | EHI_158050 | Hsc70-interacting protein, putative |
Echinococcus multilocularis | EmuJ_000887500 | mitochondrial import receptor subunit tom34 |
Giardia lamblia | GL50803_9594 | Heat shock 70kD protein binding protein |
Homo sapiens | ENSG00000100380 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) |
Leishmania braziliensis | LbrM.29.0260 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_290330.1 | TPR repeat, putative |
Leishmania infantum | LinJ.29.0330 | hypothetical protein, conserved |
Leishmania major | LmjF.29.0320 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.08_29.0320 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04405 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04403 | TPR Domain containing protein |
Mus musculus | ENSMUSG00000022403 | suppression of tumorigenicity 13 |
Neospora caninum | NCLIV_032620 | Cs1 protein, related |
Oryza sativa | 4346999 | Os09g0401200 |
Oryza sativa | 4327973 | Os02g0100300 |
Plasmodium berghei | PBANKA_1242300 | Hsc70-interacting protein |
Plasmodium falciparum | PF3D7_0527500 | Hsc70-interacting protein |
Plasmodium knowlesi | PKNH_1005200 | Hsc70-interacting protein, putative |
Plasmodium vivax | PVX_079865 | Hsc70-interacting protein, putative |
Plasmodium yoelii | PY00398 | 58 kda phosphoprotein (heat shock-related protein) (hrp). |
Schistosoma japonicum | Sjp_0200640 | ko:K09560 suppressor of tumorigenicity protein 13, putative |
Schistosoma mansoni | Smp_062420.1 | heat shock protein 70 |
Schistosoma mansoni | Smp_062420.3 | heat shock protein 70 |
Schistosoma mansoni | Smp_062420.2 | heat shock protein 70 |
Schistosoma mansoni | Smp_062420.4 | heat shock protein 70 |
Schmidtea mediterranea | mk4.000544.07 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.036208.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.009647.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.007684.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.001135.02 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000000.37 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000465.04 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.016008.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000914.03 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.018219.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.018321.04 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000010.18 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.019773.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.002838.05 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.010601.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.015599.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.026956.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.016303.02 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.031408.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.020889.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000730.02 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.002588.02 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.013569.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.008008.01 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.013061.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.012603.03 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000802.13 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.021604.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.013945.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.012335.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.018532.01 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.002566.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.008271.04 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.014611.06 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.003287.01 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.001923.06 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.031608.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000508.09 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.005337.01 | |
Schmidtea mediterranea | mk4.006734.01 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.011168.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.004123.01 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.028923.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000398.01 | |
Schmidtea mediterranea | mk4.007997.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.017783.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.007656.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000303.07 | |
Schmidtea mediterranea | mk4.002809.02 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.025056.01 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000941.07 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.011176.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.024816.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.002775.04 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.031100.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.025679.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.000751.04 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.019316.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.028208.00 | Putative heat shock protein 70 |
Schmidtea mediterranea | mk4.005504.02 | Putative heat shock protein 70 |
Trypanosoma brucei gambiense | Tbg972.3.6040 | Hsc70-interacting protein (Hip), putative |
Trypanosoma brucei | Tb927.3.5340 | Hsc70-interacting protein (Hip), putative |
Trypanosoma congolense | TcIL3000_3_3290 | Hsc70-interacting protein (Hip), putative |
Trypanosoma cruzi | TcCLB.508409.210 | Hsc70-interacting protein, putative |
Trypanosoma cruzi | TcCLB.510143.24 | Hsc70-interacting protein (Hip), putative |
Toxoplasma gondii | TGME49_232660 | Hsp70 interacting protein HIP |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.5340 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.5340 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.5340 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.5340 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_232660 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.