pI: 6.2853 |
Length (AA): 543 |
MW (Da): 59864 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
21 | 540 | 4b2t (E) | 18 | 537 | 64.00 | 0.0000000031 | 1 | 1.57634 | 0.01 |
34 | 539 | 5uyx (A) | 31 | 536 | 71.00 | 0 | 1 | 1.72556 | -0.44 |
228 | 381 | 1ass (A) | 1 | 152 | 36.00 | 0 | 1 | 0.85641 | -1.32 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127343)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G24510 | T-complex protein 1 subunit epsilon |
Babesia bovis | BBOV_II004650 | T-complex protein 1 epsilon subunit, putative |
Brugia malayi | Bm1_47485 | T-complex protein 1, epsilon subunit |
Candida albicans | CaO19.9828 | similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Candida albicans | CaO19.2288 | similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Caenorhabditis elegans | CELE_C07G2.3 | Protein CCT-5, isoform B |
Cryptosporidium hominis | Chro.70357 | CCTepsilon subunit |
Cryptosporidium parvum | cgd7_3180 | T complex chaperonin |
Dictyostelium discoideum | DDB_G0281849 | chaperonin containing TCP1 epsilon subunit |
Drosophila melanogaster | Dmel_CG8439 | T-complex Chaperonin 5 |
Echinococcus granulosus | EgrG_000717700 | chaperonin containing TCP1 subunit 5 epsilon |
Entamoeba histolytica | EHI_155450 | chaperonin containing TCP-1 epsilon subunit, putative |
Echinococcus multilocularis | EmuJ_000717700 | chaperonin containing TCP1, subunit 5 (epsilon) |
Giardia lamblia | GL50803_11992 | TCP-1 chaperonin subunit epsilon |
Homo sapiens | ENSG00000150753 | chaperonin containing TCP1, subunit 5 (epsilon) |
Leishmania braziliensis | LbrM.32.1100 | chaperonin containing t-complex protein, putative |
Leishmania donovani | LdBPK_321060.1 | chaperonin containing t-complex protein, putative |
Leishmania infantum | LinJ.32.1060 | chaperonin containing t-complex protein, putative |
Leishmania major | LmjF.32.1000 | chaperonin containing t-complex protein, putative |
Leishmania mexicana | LmxM.31.1000 | chaperonin containing t-complex protein, putative |
Loa Loa (eye worm) | LOAG_06719 | CCT-5 protein |
Mycobacterium leprae | ML0381 | 60 kDa chaperonin 1 GroEL1 (Protein Cpn60-1) (groEL protein 1) |
Mus musculus | ENSMUSG00000022234 | chaperonin containing Tcp1, subunit 5 (epsilon) |
Mycobacterium tuberculosis | Rv3417c | 60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1) |
Mycobacterium ulcerans | MUL_0886 | chaperonin GroEL |
Neospora caninum | NCLIV_022560 | Thermosome subunit, related |
Oryza sativa | 4341310 | Os06g0562600 |
Plasmodium berghei | PBANKA_1218200 | T-complex protein 1 subunit epsilon, putative |
Plasmodium falciparum | PF3D7_0320300 | T-complex protein 1 subunit epsilon |
Plasmodium knowlesi | PKNH_0820900 | T-complex protein 1 subunit epsilon, putative |
Plasmodium vivax | PVX_095220 | T-complex protein 1 subunit epsilon, putative |
Plasmodium yoelii | PY00598 | T-complex protein 1 epsilon subunit |
Saccharomyces cerevisiae | YJR064W | Cct5p |
Schistosoma japonicum | Sjp_0208180 | ko:K09497 T-complex protein 1 subunit epsilon, putative |
Schistosoma mansoni | Smp_063420 | chaperonin containing t-complex protein 1 epsilon subunit tcpe |
Schmidtea mediterranea | mk4.002150.02 | T-complex protein 1 subunit epsilon |
Trypanosoma brucei gambiense | Tbg972.11.15960 | T-complex protein 1, epsilon subunit, putative |
Trypanosoma brucei | Tb927.11.14250 | T-complex protein 1, epsilon subunit, putative |
Trypanosoma congolense | TcIL3000.11.14560 | T-complex protein 1, epsilon subunit, putative |
Trypanosoma cruzi | TcCLB.511725.250 | chaperonin containing t-complex protein, putative |
Toxoplasma gondii | TGME49_202370 | T-complex protein 1, epsilon subunit (TCP-1-epsilon), putative |
Theileria parva | TP02_0289 | T-complex protein 1, epsilon subunit, putative |
Trichomonas vaginalis | TVAG_147070 | chaperonin containing t-complex protein 1, delta subunit, tcpd, putative |
Trichomonas vaginalis | TVAG_272330 | chaperonin containing t-complex protein 1, delta subunit, tcpd, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Mycobacterium tuberculosis | essential | nmpdr | |
Tb11.01.5860 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5860 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5860 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.5860 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C07G2.3 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_C07G2.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C07G2.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C07G2.3 | Caenorhabditis elegans | sterile | wormbase |
YJR064W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1218200 | Plasmodium berghei | Essential | plasmo |
TGME49_202370 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaaca fascicularis | T-complex protein 1 subunit beta | 535 aa | 33.1% | 513 aa | Compounds | References |