Detailed view for EmuJ_000080400

Basic information

TDR Targets ID: 965322
Echinococcus multilocularis, GTP binding protein Di Ras2
Source Database / ID:  GeneDB

pI: 7.7258 | Length (AA): 222 | MW (Da): 24638 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005525   GTP binding  
GO:0003924   GTPase activity  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 179 2gf0 (A) 4 175 76.00 0 1 1.82209 -2.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131838)

Species Accession Gene Product
Brugia malayi Bm1_43695   small GTP-binding protein domain containing protein
Caenorhabditis elegans CELE_C54A12.4   Protein DRN-1
Drosophila melanogaster Dmel_CG8500   CG8500 gene product from transcript CG8500-RA
Echinococcus granulosus EgrG_000080400   GTP binding protein Di Ras2
Echinococcus granulosus EgrG_000770700   GTP binding protein Di Ras2
Echinococcus multilocularis EmuJ_000770700   GTP binding protein Di Ras2
Echinococcus multilocularis EmuJ_000080400   GTP binding protein Di Ras2
Homo sapiens ENSG00000176490   DIRAS family, GTP-binding RAS-like 1
Homo sapiens ENSG00000165023   DIRAS family, GTP-binding RAS-like 2
Loa Loa (eye worm) LOAG_03595   small GTP-binding protein domain-containing protein
Mus musculus ENSMUSG00000043670   DIRAS family, GTP-binding RAS-like 1
Mus musculus ENSMUSG00000047842   DIRAS family, GTP-binding RAS-like 2
Schistosoma japonicum Sjp_0082850   GTP-binding protein Di-Ras2, putative
Schistosoma mansoni Smp_046010   diras family GTP-binding ras-like
Schistosoma mansoni Smp_046000   diras family GTP-binding ras-like
Schmidtea mediterranea mk4.018433.00   GTP-binding protein Di-Ras3
Schmidtea mediterranea mk4.010968.00  
Schmidtea mediterranea mk4.027875.00   GTP-binding protein Di-Ras3
Schmidtea mediterranea mk4.028121.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EmuJ_000080400 (Echinococcus multilocularis), GTP binding protein Di Ras2
Title for this comment
Comment