Detailed view for EmuJ_000744100

Basic information

TDR Targets ID: 965604
Echinococcus multilocularis, cap specific mRNA
Source Database / ID:  GeneDB

pI: 8.0027 | Length (AA): 891 | MW (Da): 98518 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01585   G-patch domain
PF01728   FtsJ-like methyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0080009   GO:mRNA methylation  

GO:0004483   mRNA (nucleoside-2'-O-)-methyltransferase activity  
GO:0008168   methyltransferase activity  
GO:0003676   nucleic acid binding  
GO:0032259   methylation  
GO:0006370   mRNA capping  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
107 587 4n49 (A) 141 547 36.00 0 1 0.750843 0.23
198 413 3dou (A) 18 193 22.00 0 0.72 0.232424 0.14
820 889 5cq2 (A) 438 503 29.00 0.68 0.03 0.0415634 1.34
821 854 1e0l (A) 3 35 30.00 0.22 0.7 0.342159 0
822 855 2ysh (A) 8 40 30.00 0.31 0.17 0.294159 -0.05
822 854 2m9i (A) 2 34 39.00 0.12 0.33 0.421037 0.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129738)

Species Accession Gene Product
Brugia malayi Bm1_31430   FtsJ-like methyltransferase family protein
Caenorhabditis elegans CELE_Y53F4B.13   Protein Y53F4B.13, isoform D
Dictyostelium discoideum DDB_G0271428   hypothetical protein
Dictyostelium discoideum DDB_G0279593   D111/G-patch domain-containing protein
Drosophila melanogaster Dmel_CG6379   CG6379 gene product from transcript CG6379-RB
Echinococcus granulosus EgrG_000744100   cap specific mRNA
Echinococcus multilocularis EmuJ_000744100   cap specific mRNA
Giardia lamblia GL50803_103058   Methyltransferase, putative
Giardia lamblia GL50803_100887   Methyltransferase, putative
Homo sapiens ENSG00000137200   cap methyltransferase 1
Leishmania braziliensis LbrM.35.7020   methyltransferase, putative,ensangp00000010174-like protein
Leishmania donovani LdBPK_366970.1   methyltransferase, putative
Leishmania infantum LinJ.36.6970   methyltransferase, putative,ensangp00000010174-like protein
Leishmania major LmjF.36.6660   methyltransferase, putative,ensangp00000010174-like protein
Leishmania mexicana LmxM.36.6660   methyltransferase, putative,ensangp00000010174-like protein
Loa Loa (eye worm) LOAG_08398   hypothetical protein
Mus musculus 74157   cap methyltransferase 1
Schistosoma japonicum Sjp_0046810   ko:K03143 transcription initiation factor TFIIH subunit H3, putative
Schistosoma japonicum Sjp_0046820   similar to Uncharacterized protein KIAA0082 homolog, putative
Schistosoma mansoni Smp_182200   hypothetical protein
Schistosoma mansoni Smp_186690   hypothetical protein
Schistosoma mansoni Smp_046180   hypothetical protein
Schistosoma mansoni Smp_122770   hypothetical protein
Schistosoma mansoni Smp_122730   hypothetical protein
Schistosoma mansoni Smp_108950   hypothetical protein
Schistosoma mansoni Smp_192160   hypothetical protein
Schistosoma mansoni Smp_117450   hypothetical protein
Schmidtea mediterranea mk4.002152.02   Cap-specific mRNA
Schmidtea mediterranea mk4.003505.02   Cap-specific mRNA
Trypanosoma brucei gambiense Tbg972.10.9720   methyltransferase, putative
Trypanosoma brucei Tb927.10.7940   methyltransferase, putative
Trypanosoma congolense TcIL3000_10_6820   methyltransferase, putative
Trypanosoma cruzi TcCLB.506247.320   methyltransferase, putative
Trichomonas vaginalis TVAG_116350   conserved hypothetical protein

Essentiality

EmuJ_000744100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.7940 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.7940 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.7940 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.7940 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y53F4B.13 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier EmuJ_000744100 (Echinococcus multilocularis), cap specific mRNA
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