pI: 5.7608 |
Length (AA): 199 |
MW (Da): 22613 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 111 | 5azw (A) | 21 | 113 | 54.00 | 0 | 1 | 1.24434 | -1.44 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127521)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G22845 | transmembrane emp24 domain-containing protein p24beta3 |
Babesia bovis | BBOV_IV006450 | conserved hypothetical protein |
Brugia malayi | Bm1_45445 | Suppressor/enhancer of lin-12 protein 9 precursor, putative |
Candida albicans | CaO19.3889 | component of COPII-coated ER-derived vesicles |
Candida albicans | CaO19.13672 | component of COPII-coated, ER transport vesicles |
Candida albicans | CaO19.6293 | component of COPII-coated, ER transport vesicles |
Candida albicans | CaO19.11370 | component of COPII-coated ER-derived vesicles |
Candida albicans | CaO19.3558 | protein involved in membrane trafficking. |
Candida albicans | CaO19.11042 | protein involved in membrane trafficking. |
Caenorhabditis elegans | CELE_W02D7.7 | Protein SEL-9 |
Cryptosporidium hominis | Chro.70216 | CG9308-PA |
Cryptosporidium parvum | cgd7_1860 | P24 like gold domain protein, possible transmembrane region near C-terminus, signal peptide |
Dictyostelium discoideum | DDB_G0293540 | hypothetical protein |
Dictyostelium discoideum | DDB_G0288053 | hypothetical protein |
Drosophila melanogaster | Dmel_CG9308 | CG9308 gene product from transcript CG9308-RA |
Drosophila melanogaster | Dmel_CG3564 | CG3564 gene product from transcript CG3564-RB |
Echinococcus granulosus | EgrG_000574700 | transmembrane emp24 domain containing protein |
Entamoeba histolytica | EHI_096210 | Coated vesicle membrane protein, putative |
Entamoeba histolytica | EHI_038590 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000574700 | transmembrane emp24 domain containing protein |
Giardia lamblia | GL50803_4509 | ERP1 |
Homo sapiens | ENSG00000086598 | transmembrane emp24 domain trafficking protein 2 |
Leishmania braziliensis | LbrM.32.2230 | cop-coated vesicle membrane protein p24 precursor, putative,ER--golgi transport protein p24, putative |
Leishmania donovani | LdBPK_322150.1 | cop-coated vesicle membrane protein p24 precursor, putative |
Leishmania infantum | LinJ.32.2150 | cop-coated vesicle membrane protein p24 precursor, putative,ER--golgi transport protein p24, putative |
Leishmania major | LmjF.32.2020 | cop-coated vesicle membrane protein p24 precursor, putative,ER--golgi transport protein p24, putative |
Leishmania mexicana | LmxM.31.2020 | cop-coated vesicle membrane protein p24 precursor, putative,ER--golgi transport protein p24, putative |
Loa Loa (eye worm) | LOAG_01105 | SEL-9 protein |
Mus musculus | ENSMUSG00000029390 | transmembrane emp24 domain trafficking protein 2 |
Mus musculus | 100862175 | predicted gene, 21540 |
Oryza sativa | 4334079 | Os03g0744800 |
Plasmodium berghei | PBANKA_1413000 | cop-coated vesicle membrane protein p24 precursor, putative |
Plasmodium falciparum | PF3D7_1314500 | cop-coated vesicle membrane protein p24 precursor, putative |
Plasmodium knowlesi | PKNH_1415100 | cop-coated vesicle membrane protein p24 precursor, putative |
Plasmodium vivax | PVX_122545 | cop-coated vesicle membrane protein p24 precursor, putative |
Plasmodium yoelii | PY00476 | hypothetical protein |
Saccharomyces cerevisiae | YGL200C | Emp24p |
Saccharomyces cerevisiae | YDL018C | Erp3p |
Schistosoma japonicum | Sjp_0036440 | Transmembrane emp24 domain-containing protein 2 precursor, putative |
Schistosoma mansoni | Smp_046250 | copii-coated vesicle membrane protein P24 |
Schmidtea mediterranea | mk4.004702.00 | CHOp24 |
Schmidtea mediterranea | mk4.002151.02 | CHOp24 |
Schmidtea mediterranea | mk4.001928.02 | EMP24 |
Schmidtea mediterranea | mk4.001629.04 | Suppressor/enhancer of lin-12 protein 9 |
Trypanosoma brucei gambiense | Tbg972.11.17110 | cytosolic coat protein, putative |
Trypanosoma brucei | Tb927.11.15230 | cytosolic coat protein, putative |
Trypanosoma congolense | TcIL3000.11.15380 | cytosolic coat protein, putative |
Trypanosoma cruzi | TcCLB.511711.90 | cop-coated vesicle membrane protein p24 precursor, putative |
Trypanosoma cruzi | TcCLB.503987.10 | cop-coated vesicle membrane protein p24 precursor, putative |
Theileria parva | TP01_1195 | cop-coated vesicle membrane protein p24 precursor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.6880 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.6880 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.6880 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.6880 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_W02D7.7 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_W02D7.7 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1413000 | Plasmodium berghei | Dispensable | plasmo |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.