Detailed view for EmuJ_001165800

Basic information

TDR Targets ID: 965742
Echinococcus multilocularis, sodium:potassium:calcium exchanger
Source Database / ID:  GeneDB

pI: 6.1782 | Length (AA): 605 | MW (Da): 67526 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01699   Sodium/calcium exchanger protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
46 121 1a4p (A) 21 91 35.00 0.26 0.4 0.38992 0.49
135 236 4kjr (A) 243 350 31.00 0.95 0.01 0.076895 2.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129598)

Species Accession Gene Product
Brugia malayi Bm1_51165   K+-dependent Na+/Ca+ exchanger related-protein
Drosophila melanogaster Dmel_CG1090   CG1090 gene product from transcript CG1090-RI
Drosophila melanogaster Dmel_CG2893   zydeco
Echinococcus granulosus EgrG_001165800   sodium:potassium:calcium exchanger
Echinococcus multilocularis EmuJ_001165800   sodium:potassium:calcium exchanger
Homo sapiens ENSG00000140090   solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Homo sapiens ENSG00000185052   solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Loa Loa (eye worm) LOAG_07867   hypothetical protein
Mus musculus ENSMUSG00000063873   solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Mus musculus ENSMUSG00000041771   solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Schistosoma japonicum Sjp_0008120   Probable sodium/potassium/calcium exchanger CG1090, putative
Schistosoma japonicum Sjp_0008110   Sodium/potassium/calcium exchanger 4 precursor, putative
Schistosoma mansoni Smp_170370   potassium-dependent sodium-calcium exchanger 3 4
Schistosoma mansoni Smp_170450   hypothetical protein
Schmidtea mediterranea mk4.012255.01  
Schmidtea mediterranea mk4.014456.00  
Schmidtea mediterranea mk4.026098.00   Sodium/potassium/calcium exchanger Nckx30C
Schmidtea mediterranea mk4.014456.02  
Schmidtea mediterranea mk4.005773.00   Sodium/potassium/calcium exchanger 5
Schmidtea mediterranea mk4.000561.10   Sodium/potassium/calcium exchanger Nckx30C
Schmidtea mediterranea mk4.014456.01  
Schmidtea mediterranea mk4.008331.00   Sodium/potassium/calcium exchanger 5
Schmidtea mediterranea mk4.019280.00  
Schmidtea mediterranea mk4.013999.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_001165800 (Echinococcus multilocularis), sodium:potassium:calcium exchanger
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